Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)

Yasunobu Matsumoto, Kazuhiro Hibino, Masahiro Yonaga, Hideaki Kakeya, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The first total synthesis of RQN-18690A (18-deoxyherboxidiene) and the determination of its absolute stereochemical configuration are described. The synthesis features an organocatalytic aldol reaction for the first step, 1,4- and 1,2- dual reductions of α,β-unsaturated δ-lactone followed by a domino reaction in a one-pot operation, and diastereoselective epoxidation with kinetic resolution.

Original languageEnglish
Pages (from-to)3382-3385
Number of pages4
JournalOrganic Letters
Issue number14
Publication statusPublished - 2016 Jul 15


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