Enarodustat to treat anemia in chronic kidney disease

K. Fukui, T. Tanaka, M. Nangaku

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Anemia is a common complication in patients with chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) are the standard therapy for anemia in CKD. It has been expected that hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibition may have the potential to provide therapeutic benefits over pre-existing ESAs for anemia in CKD. Enarodustat (JTZ-951) is an oral HIF-PH inhibitor. In preclinical studies, enarodustat has been found to increase HIF-α proteins, erythropoietin production and erythropoiesis. Enarodustat also shows efficient iron utilization in iron-related parameters during erythropoiesis. Clinical trials have shown that enarodustat improved anemia both in non-dialysis-dependent CKD patients and dialysis patients. The safety results in clinical trials demonstrate that enarodustat is generally well tolerated. On the basis of these results, enarodustat was approved in September 2020 in Japan for the treatment of anemia associated with CKD. This manuscript will review enarodustat, its pharmacological characteristics in preclinical studies, and its efficacy and safety in clinical trials with anemic patients in CKD.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalDrugs of Today
Issue number8
Publication statusPublished - 2021 Aug
Externally publishedYes


  • Anemia
  • Antianemics
  • Chronic kidney disease
  • Enarodustat
  • Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors
  • Renal disorders

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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