Endothelin-like immunoreactivity in human breast cyst fluid

Kazuhiro Takahashi, Leslie C. Lap, Mohammad A. Ghatei, Vivian H.T. James, Stephen R. Bloom

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Immunoreactive endothelin has been detected in 21 of 43 samples of breast cyst fluid (21 cases; 3.5 ± 0.6 pmol/1, moan ± SEM. Other 22 cases; not detectable, <0.5pmol/1). Fast protein liquid chromatographic analysis of the immunoreactive endothelin of pooled breast cyst fluid showed two immunoreactive peaks; one in the void volume and the other in the position of endothelin-1. It is probable that endothelin-1 is produced by the epithelial cells lining breast cysts, but significance of the presence of cndothelin-1 in breast cyst fluid remains to be elucidated.

Original languageEnglish
Pages (from-to)1681-1683
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
Publication statusPublished - 1990 Dec


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