Enhanced Plasma GH Responses to Simultaneous Administration of TRH and GHRH in Patients with Primary Hypothyroidism

Kunihiko Hanew; Atsushi Utsumi; Akira Sugawara; Aki Tanaka; Hiroshi Fukazawa; Katsumi Yoshida; Keishi Abe; Kunihiko Hanew

doi:10.1507/endocrj.42.43

Enhanced Plasma GH Responses to Simultaneous Administration of TRH and GHRH in Patients with Primary Hypothyroidism

Kunihiko Hanew, Atsushi Utsumi, Akira Sugawara, Aki Tanaka, Hiroshi Fukazawa, Katsumi Yoshida, Keishi Abe, Kunihiko Hanew

MED - Health Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The mechanism of aberrant GH responses to TRH was indirectly evaluated in 7 patients with primary hypothyroidism. All patients showed GH response to TRH. When TRH was administered together with GHRH, the plasma GH response was much greater than after a single administration of TRH or GHRH (TRH+GHRH vs. TRH or GHRH: max. Δ GH, 16.4±3.2vs. 5.4±1.3 or 6.0±0.8μg/L; AUC, 1282.7±234.7vs. 384.0±95.0 or 441.8±66.2, both P <0.01). The combined administration of TRH and GHRH caused an additive, but not a synergistic, GH response. In contrast, 8 normal subjects showed neither any plasma GH response to TRH nor enhancement by TRH of GHRH-induced GH response following combined administration. It is concluded that the sites of action of TRH seemed to be different from GHRH in patients with primary hypothyroidism.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Endocrine Journal
Volume	42
Issue number	1
DOIs	https://doi.org/10.1507/endocrj.42.43
Publication status	Published - 1995

Keywords

GHRH
Plasma GH
Primary hypothyroidism
TRH

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title = "Enhanced Plasma GH Responses to Simultaneous Administration of TRH and GHRH in Patients with Primary Hypothyroidism",

abstract = "The mechanism of aberrant GH responses to TRH was indirectly evaluated in 7 patients with primary hypothyroidism. All patients showed GH response to TRH. When TRH was administered together with GHRH, the plasma GH response was much greater than after a single administration of TRH or GHRH (TRH+GHRH vs. TRH or GHRH: max. Δ GH, 16.4±3.2vs. 5.4±1.3 or 6.0±0.8μg/L; AUC, 1282.7±234.7vs. 384.0±95.0 or 441.8±66.2, both P <0.01). The combined administration of TRH and GHRH caused an additive, but not a synergistic, GH response. In contrast, 8 normal subjects showed neither any plasma GH response to TRH nor enhancement by TRH of GHRH-induced GH response following combined administration. It is concluded that the sites of action of TRH seemed to be different from GHRH in patients with primary hypothyroidism.",

keywords = "GHRH, Plasma GH, Primary hypothyroidism, TRH",

author = "Kunihiko Hanew and Atsushi Utsumi and Akira Sugawara and Aki Tanaka and Hiroshi Fukazawa and Katsumi Yoshida and Keishi Abe and Kunihiko Hanew",

year = "1995",

doi = "10.1507/endocrj.42.43",

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T1 - Enhanced Plasma GH Responses to Simultaneous Administration of TRH and GHRH in Patients with Primary Hypothyroidism

AU - Hanew, Kunihiko

AU - Utsumi, Atsushi

AU - Sugawara, Akira

AU - Tanaka, Aki

AU - Fukazawa, Hiroshi

AU - Yoshida, Katsumi

AU - Abe, Keishi

AU - Hanew, Kunihiko

PY - 1995

Y1 - 1995

N2 - The mechanism of aberrant GH responses to TRH was indirectly evaluated in 7 patients with primary hypothyroidism. All patients showed GH response to TRH. When TRH was administered together with GHRH, the plasma GH response was much greater than after a single administration of TRH or GHRH (TRH+GHRH vs. TRH or GHRH: max. Δ GH, 16.4±3.2vs. 5.4±1.3 or 6.0±0.8μg/L; AUC, 1282.7±234.7vs. 384.0±95.0 or 441.8±66.2, both P <0.01). The combined administration of TRH and GHRH caused an additive, but not a synergistic, GH response. In contrast, 8 normal subjects showed neither any plasma GH response to TRH nor enhancement by TRH of GHRH-induced GH response following combined administration. It is concluded that the sites of action of TRH seemed to be different from GHRH in patients with primary hypothyroidism.

AB - The mechanism of aberrant GH responses to TRH was indirectly evaluated in 7 patients with primary hypothyroidism. All patients showed GH response to TRH. When TRH was administered together with GHRH, the plasma GH response was much greater than after a single administration of TRH or GHRH (TRH+GHRH vs. TRH or GHRH: max. Δ GH, 16.4±3.2vs. 5.4±1.3 or 6.0±0.8μg/L; AUC, 1282.7±234.7vs. 384.0±95.0 or 441.8±66.2, both P <0.01). The combined administration of TRH and GHRH caused an additive, but not a synergistic, GH response. In contrast, 8 normal subjects showed neither any plasma GH response to TRH nor enhancement by TRH of GHRH-induced GH response following combined administration. It is concluded that the sites of action of TRH seemed to be different from GHRH in patients with primary hypothyroidism.

KW - GHRH

KW - Plasma GH

KW - Primary hypothyroidism

KW - TRH

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Enhanced Plasma GH Responses to Simultaneous Administration of TRH and GHRH in Patients with Primary Hypothyroidism

Abstract

Keywords

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