Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake

Taro Nihei; Jun Takahashi; Yoku Kikuchi; Yusuke Takagi; Kiyotaka Hao; Ryuji Tsuburaya; Takashi Shiroto; Yoshitaka Ito; Yasuharu Matsumoto; Masaharu Nakayama; Kenta Ito; Satoshi Yasuda; Hiroaki Shimokawa

doi:10.1253/circj.CJ-12-1238

Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake

Taro Nihei, Jun Takahashi, Yoku Kikuchi, Yusuke Takagi, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. Conclusions: These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.

Original language	English
Pages (from-to)	2892-2894
Number of pages	3
Journal	Circulation Journal
Volume	76
Issue number	12
DOIs	https://doi.org/10.1253/circj.CJ-12-1238
Publication status	Published - 2012

Keywords

Angina
Stress
Vasospasm

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-12-1238

Cite this

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title = "Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake",

abstract = "Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. Conclusions: These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.",

keywords = "Angina, Stress, Vasospasm",

author = "Taro Nihei and Jun Takahashi and Yoku Kikuchi and Yusuke Takagi and Kiyotaka Hao and Ryuji Tsuburaya and Takashi Shiroto and Yoshitaka Ito and Yasuharu Matsumoto and Masaharu Nakayama and Kenta Ito and Satoshi Yasuda and Hiroaki Shimokawa",

year = "2012",

doi = "10.1253/circj.CJ-12-1238",

language = "English",

volume = "76",

pages = "2892--2894",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

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TY - JOUR

T1 - Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake

AU - Nihei, Taro

AU - Takahashi, Jun

AU - Kikuchi, Yoku

AU - Takagi, Yusuke

AU - Hao, Kiyotaka

AU - Tsuburaya, Ryuji

AU - Shiroto, Takashi

AU - Ito, Yoshitaka

AU - Matsumoto, Yasuharu

AU - Nakayama, Masaharu

AU - Ito, Kenta

AU - Yasuda, Satoshi

AU - Shimokawa, Hiroaki

PY - 2012

Y1 - 2012

N2 - Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. Conclusions: These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.

AB - Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. Conclusions: These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.

KW - Angina

KW - Stress

KW - Vasospasm

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SN - 1346-9843

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JO - Circulation Journal

JF - Circulation Journal

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ER -

Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake

Abstract

Keywords

ASJC Scopus subject areas

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