TY - JOUR
T1 - Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension
T2 - A preliminary observational study
AU - Tatebe, Shunsuke
AU - Fukumoto, Yoshihiro
AU - Oikawa-Wakayama, Minako
AU - Sugimura, Koichiro
AU - Satoh, Kimio
AU - Miura, Yutaka
AU - Aoki, Tatsuo
AU - Nochioka, Kotaro
AU - Miura, Masanobu
AU - Yamamoto, Saori
AU - Tashiro, Manabu
AU - Kagaya, Yutaka
AU - Shimokawa, Hiroaki
PY - 2014/6
Y1 - 2014/6
N2 - AimsWe have previously demonstrated that [18F]fluorodeoxyglucose (FDG) accumulation is increased in the right ventricular (RV) free wall of patients with pulmonary hypertension (PH), and that this accumulation is ameliorated after the treatment with epoprostenol associated with improvement of haemodynamic overload. The aim of this study was to examine whether enhanced RV FDG accumulation by gated positron emission tomography (PET) has a prognostic impact in patients with PH.Methods and resultsWe examined the prognostic impact of the RV standardized uptake value (SUV) of FDG-PET corrected for the partial volume effect (cRV-SUV) in 27 patients with PH who underwent gated FDG-PET from March 2001 to June 2004. During the follow-up period of 69 ± 49 (mean ± SD) months, among the 27 patients, 15 showed clinical worsening (CW) and 11 died. FDG-PET examination showed that cRV-SUV was significantly higher in the CW group compared with the non-CW group (10.1 vs. 7.6, P 0.02). Univariate Cox hazard analysis showed that cRV-SUV was significantly correlated with the time to CW (hazard ratio 1.25, 95 confidence interval 1.04-1.51, P 0.02), which remained significant even after adjustment of World Health Organization functional class. Kaplan-Meier analysis showed that the patients with cRV-SUV <8.3 had poor prognosis compared with those with cRV-SUV <8.3 (log-rank P 0.005 for time to CW and P 0.07 for mortality).ConclusionThese results indicate that enhanced FDG accumulation in the RV free wall may be a novel prognostic factor in patients with PH.
AB - AimsWe have previously demonstrated that [18F]fluorodeoxyglucose (FDG) accumulation is increased in the right ventricular (RV) free wall of patients with pulmonary hypertension (PH), and that this accumulation is ameliorated after the treatment with epoprostenol associated with improvement of haemodynamic overload. The aim of this study was to examine whether enhanced RV FDG accumulation by gated positron emission tomography (PET) has a prognostic impact in patients with PH.Methods and resultsWe examined the prognostic impact of the RV standardized uptake value (SUV) of FDG-PET corrected for the partial volume effect (cRV-SUV) in 27 patients with PH who underwent gated FDG-PET from March 2001 to June 2004. During the follow-up period of 69 ± 49 (mean ± SD) months, among the 27 patients, 15 showed clinical worsening (CW) and 11 died. FDG-PET examination showed that cRV-SUV was significantly higher in the CW group compared with the non-CW group (10.1 vs. 7.6, P 0.02). Univariate Cox hazard analysis showed that cRV-SUV was significantly correlated with the time to CW (hazard ratio 1.25, 95 confidence interval 1.04-1.51, P 0.02), which remained significant even after adjustment of World Health Organization functional class. Kaplan-Meier analysis showed that the patients with cRV-SUV <8.3 had poor prognosis compared with those with cRV-SUV <8.3 (log-rank P 0.005 for time to CW and P 0.07 for mortality).ConclusionThese results indicate that enhanced FDG accumulation in the RV free wall may be a novel prognostic factor in patients with PH.
KW - Fluorodeoxyglucose
KW - Myocardial energy substrate metabolism
KW - Positron emission tomography
KW - Prognosis
KW - Pulmonary hypertension
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U2 - 10.1093/ehjci/jet276
DO - 10.1093/ehjci/jet276
M3 - Article
C2 - 24408936
AN - SCOPUS:84901272675
SN - 2047-2404
VL - 15
SP - 666
EP - 672
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
IS - 6
ER -