Enhancement of Hemocompatibility of the MERA Monopivot Centrifugal Pump: Toward Medium-Term Use

Takashi Yamane, Ryo Kosaka, Masahiro Nishida, Osamu Maruyama, Yoshihiro Yamamoto, Katsuyuki Kuwana, Hiroshi Kawamura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshiyuki Sankai, Tatsuo Tsutsui

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The MERA monopivot centrifugal pump has been developed for use in open-heart surgery, circulatory support, and bridge-to-decision for up to 4weeks. The pump has a closed-type, 50-mm diameter impeller with four straight paths. The impeller is supported by a monopivot bearing and is driven by a radial-flux magnet-coupling motor. Because flow visualization experiments have clarified sufficient pivot wash and stagnation at the sharp corner of the pivot support was suggested, sharp corners were removed in the design stage. The index of hemolysis of the pump operating at more than 200mmHg was found to be lower than that of a commercial pump. Four-week animal tests were then conducted two times; improvement of thrombus formation was seen in the female pivot through modification of female pivot geometry. Overall antithrombogenicity was also recorded. Finally, to assure mid-term use, an additional 4-week durability test revealed that the rate of the axial pivot wear was as small as 1.1μm/day. The present in vitro and in vivo studies revealed that the MERA monopivot centrifugal pump has sufficient hemocompatibility and durability for up to 4weeks. Artificial Organs

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalArtificial Organs
Issue number2
Publication statusPublished - 2013 Feb


  • Artificial heart
  • Bridge-to-decision
  • Centrifugal pump
  • Circulatory assist
  • Durability test
  • Hemolysis test
  • In vitro thrombogenicity test
  • Monopivot

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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