Enhancement of high-intensity focused ultrasound heating by short-pulse generated cavitation

Shin Yoshizawa, Ryo Takagi, Shin Ichiro Umemura

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named "trigger HIFU exposure" which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

Original languageEnglish
Article number288
JournalApplied Sciences (Switzerland)
Issue number3
Publication statusPublished - 2017


  • Cavitation
  • Focused ultrasound
  • HIFU
  • Microbubble
  • Ultrasound imaging


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