Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Jun Ichiro Jo; Masaya Yamamoto; Arimichi Okazaki; Tomonori Ikai; Yoshiaki Hirano; Yasuhiko Tabata

Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Jun Ichiro Jo, Masaya Yamamoto, Arimichi Okazaki, Tomonori Ikai, Yoshiaki Hirano, Yasuhiko Tabata

ENG - Materials Processing

Research output: Contribution to conference › Paper › peer-review

5 Citations (Scopus)

Abstract

The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

Original language	English
Pages	2142
Number of pages	1
Publication status	Published - 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Adult stem cells
Cationized polysaccharide derivatives
Gene transfection

Cite this

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abstract = "The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE{\texttrademark} commercially available.",

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TY - CONF

T1 - Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

AU - Jo, Jun Ichiro

AU - Yamamoto, Masaya

AU - Okazaki, Arimichi

AU - Ikai, Tomonori

AU - Hirano, Yoshiaki

AU - Tabata, Yasuhiko

PY - 2005

Y1 - 2005

N2 - The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

AB - The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

KW - Adult stem cells

KW - Cationized polysaccharide derivatives

KW - Gene transfection

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M3 - Paper

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T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Abstract

Conference

Keywords

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