Enhancement of TFO triplex formation by conjugation with pyrene via click chemistry

Yosuke Taniguchi; Akira Tomizaki; Nozomu Matsueda; Hidenori Okamura; Shigeki Sasaki

doi:10.1248/cpb.c15-00570

Enhancement of TFO triplex formation by conjugation with pyrene via click chemistry

Yosuke Taniguchi, Akira Tomizaki, Nozomu Matsueda, Hidenori Okamura, Shigeki Sasaki

IMRAM - Division of Organic- and Biomaterials Research

Kyushu University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.

Original language	English
Pages (from-to)	920-926
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	11
DOIs	https://doi.org/10.1248/cpb.c15-00570
Publication status	Published - 2015 Nov 1

Keywords

Antigene
Artificial nucleoside
Triplex-forming oligonucleotide

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abstract = "This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.",

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AU - Tomizaki, Akira

AU - Matsueda, Nozomu

AU - Okamura, Hidenori

AU - Sasaki, Shigeki

PY - 2015/11/1

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AB - This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.

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KW - Artificial nucleoside

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Enhancement of TFO triplex formation by conjugation with pyrene via click chemistry

Abstract

Keywords

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