Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates

Takao Inoue, Masami Fujii, Hiroyuki Kida, Toshitaka Yamakawa, Yuichi Maruta, Tatsuji Tokiwa, Yeting He, Sadahiro Nomura, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki

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12 Citations (Scopus)


Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate can reduce or terminate focal neocortical seizures without having a significant impact on brain tissue. Two cats and two macaque monkeys were chronically implanted with an epidural FBC device over the somatosensory and motor cortex. Penicillin G was delivered via the intracranial cannula for induction of local seizures. Repetitive FBC was performed using a cooling device implanted for a medium-term period (FBC for 30 min at least twice every week; 3 months total) in three of the four animals. The animals exhibited seizures with repetitive epileptiform discharges (EDs) after administration of penicillin G, and these discharges decreased at less than 20 °C cooling with no adverse histological effects. The results of this study suggest that epidural FBC is a safe and effective potential treatment for IE and SE.

Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalNeuroscience Research
Publication statusPublished - 2017 Sept


  • Epilepsy
  • Focal brain cooling
  • Hypothermia
  • Implantable device
  • Motor cortex
  • Neuromodulation
  • Penicillin G


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