Epigenetic alterations in human sperm

Naoko Miyauchi; Akane Kitamura; Hitoshi Hiura; Hiroaki Okae; Norio Kobayashi; Hiromitsu Hattori; Souta Takahashi; Takahiro Arima

doi:10.1007/978-3-319-55530-0_28

Epigenetic alterations in human sperm

Naoko Miyauchi, Akane Kitamura, Hitoshi Hiura, Hiroaki Okae, Norio Kobayashi, Hiromitsu Hattori, Souta Takahashi, Takahiro Arima

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The concept called developmental origins of health and disease (DOHaD) pays attention to the environmental influence on the fetus in utero (maternal side). However, individual mammals originate from the oocyte and sperm. Sperm are more susceptible to genetic and epigenetic mutations than oocytes because of the multistep germ cell meiosis during spermatogenesis (paternal side). DNA methylation might be influenced by external environmental factors such as endocrine disruptors, certain foods, and drug exposures during gametogenesis. In aged men these factors accumulate and affect the quality of sperm. Recent work identified sperm from men of advanced aged as a risk factor for autism, depression, epilepsy, and some kinds of cancer in children. In this chapter, we introduce the concept that methylation errors of paternal sperm may lead to congenital disease and various diseases later in life, and we would like to suggest the "expanded DOHaD hypothesis."

Original language	English
Title of host publication	Handbook of Nutrition, Diet, and Epigenetics
Publisher	Springer International Publishing
Pages	1161-1176
Number of pages	16
Volume	2
ISBN (Electronic)	9783319555300
ISBN (Print)	9783319555294
DOIs	https://doi.org/10.1007/978-3-319-55530-0_28
Publication status	Published - 2019 Jan 5

Keywords

ART (assisted reproductive technology)
DNA methylation
DOHaD (Developmental origins of health and disease)
Genomic imprinting
Human sperm
Imprinting disorders
Transgenerational effect

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-55530-0_28

Cite this

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AU - Miyauchi, Naoko

AU - Kitamura, Akane

AU - Hiura, Hitoshi

AU - Okae, Hiroaki

AU - Kobayashi, Norio

AU - Hattori, Hiromitsu

AU - Takahashi, Souta

AU - Arima, Takahiro

PY - 2019/1/5

Y1 - 2019/1/5

N2 - The concept called developmental origins of health and disease (DOHaD) pays attention to the environmental influence on the fetus in utero (maternal side). However, individual mammals originate from the oocyte and sperm. Sperm are more susceptible to genetic and epigenetic mutations than oocytes because of the multistep germ cell meiosis during spermatogenesis (paternal side). DNA methylation might be influenced by external environmental factors such as endocrine disruptors, certain foods, and drug exposures during gametogenesis. In aged men these factors accumulate and affect the quality of sperm. Recent work identified sperm from men of advanced aged as a risk factor for autism, depression, epilepsy, and some kinds of cancer in children. In this chapter, we introduce the concept that methylation errors of paternal sperm may lead to congenital disease and various diseases later in life, and we would like to suggest the "expanded DOHaD hypothesis."

AB - The concept called developmental origins of health and disease (DOHaD) pays attention to the environmental influence on the fetus in utero (maternal side). However, individual mammals originate from the oocyte and sperm. Sperm are more susceptible to genetic and epigenetic mutations than oocytes because of the multistep germ cell meiosis during spermatogenesis (paternal side). DNA methylation might be influenced by external environmental factors such as endocrine disruptors, certain foods, and drug exposures during gametogenesis. In aged men these factors accumulate and affect the quality of sperm. Recent work identified sperm from men of advanced aged as a risk factor for autism, depression, epilepsy, and some kinds of cancer in children. In this chapter, we introduce the concept that methylation errors of paternal sperm may lead to congenital disease and various diseases later in life, and we would like to suggest the "expanded DOHaD hypothesis."

KW - ART (assisted reproductive technology)

KW - DNA methylation

KW - DOHaD (Developmental origins of health and disease)

KW - Genomic imprinting

KW - Human sperm

KW - Imprinting disorders

KW - Transgenerational effect

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SN - 9783319555294

VL - 2

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EP - 1176

BT - Handbook of Nutrition, Diet, and Epigenetics

PB - Springer International Publishing

ER -

Epigenetic alterations in human sperm

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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