Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb

Yu Ichiro Nakajima, Matthew C. Gibson

Research output: Contribution to journalShort surveypeer-review

6 Citations (Scopus)


The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.

Original languageEnglish
Pages (from-to)R43-R45
JournalCurrent Biology
Issue number1
Publication statusPublished - 2015 Jan 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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