Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb

Yu Ichiro Nakajima; Matthew C. Gibson

doi:10.1016/j.cub.2014.11.052

Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb

Yu Ichiro Nakajima, Matthew C. Gibson

Research output: Contribution to journal › Short survey › peer-review

6 Citations (Scopus)

Abstract

The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.

Original language	English
Pages (from-to)	R43-R45
Journal	Current Biology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.cub.2014.11.052
Publication status	Published - 2015 Jan 5
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1016/j.cub.2014.11.052

Cite this

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title = "Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb",

abstract = "The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.",

author = "Nakajima, {Yu Ichiro} and Gibson, {Matthew C.}",

year = "2015",

month = jan,

day = "5",

doi = "10.1016/j.cub.2014.11.052",

language = "English",

volume = "25",

pages = "R43--R45",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "1",

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TY - JOUR

T1 - Epithelial cell division

T2 - Aurora kicks Lgl to the cytoplasmic curb

AU - Nakajima, Yu Ichiro

AU - Gibson, Matthew C.

PY - 2015/1/5

Y1 - 2015/1/5

N2 - The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.

AB - The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.

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UR - http://www.scopus.com/inward/citedby.url?scp=84920381271&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2014.11.052

DO - 10.1016/j.cub.2014.11.052

M3 - Short survey

AN - SCOPUS:84920381271

SN - 0960-9822

VL - 25

SP - R43-R45

JO - Current Biology

JF - Current Biology

IS - 1

ER -

Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb

Abstract

ASJC Scopus subject areas

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