Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome

Y. Sasahara; H. Fujie; S. Kumaki; Y. Ohashi; M. Minegishi; S. Tsuchiya; S. L. Johnston

doi:10.1111/j.1651-2227.2001.tb01589.x

Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome

Y. Sasahara, H. Fujie, S. Kumaki, Y. Ohashi, M. Minegishi, S. Tsuchiya, S. L. Johnston

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y. Conclusion: This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.

Original language	English
Pages (from-to)	1348-1351
Number of pages	4
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	90
Issue number	11
DOIs	https://doi.org/10.1111/j.1651-2227.2001.tb01589.x
Publication status	Published - 2001

Keywords

Epstein-Barr virus
Hodgkin's disease
Latent membrane protein-1
Wiskott-Aldrich syndrome

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10.1111/j.1651-2227.2001.tb01589.x

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title = "Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome",

abstract = "Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y. Conclusion: This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.",

keywords = "Epstein-Barr virus, Hodgkin's disease, Latent membrane protein-1, Wiskott-Aldrich syndrome",

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T1 - Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome

AU - Sasahara, Y.

AU - Fujie, H.

AU - Kumaki, S.

AU - Ohashi, Y.

AU - Minegishi, M.

AU - Tsuchiya, S.

AU - Johnston, S. L.

PY - 2001

Y1 - 2001

N2 - Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y. Conclusion: This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.

AB - Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y. Conclusion: This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.

KW - Epstein-Barr virus

KW - Hodgkin's disease

KW - Latent membrane protein-1

KW - Wiskott-Aldrich syndrome

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Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome

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