Estimation of possible errors in DNA computing

Yohei Aoi, Tatsuo Yoshinobu, Katsuyuki Tanizawa, Kozo Kinoshita, Hiroshi Iwasaki

Research output: Contribution to journalArticlepeer-review


DNA computing is a novel method of computing proposed by L. M. Adleman [Science 266 (1994) 1021], in which the data is encoded in the sequences of oligonucleotides. Massively parallel reactions between oligonucleotides are expected to make it possible to solve huge problems. In this study, reliability of the ligation process employed in the DNA computing is tested by estimating the error rate at which wrong oligonucleotides are ligated. Ligation of wrong oligonucleotides would result in a wrong answer in the DNA computing. The dependence of the error rate on the number of mismatches between oligonucleotides and on the combination of bases is investigated.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalTechnology Reports of the Osaka University
Issue number2319-2337
Publication statusPublished - 1998 Oct 15


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