Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/-) knockout mice

Naoki Shida, Hidetoshi Ikeda, Takashi Yoshimoto, Masanobu Oshima, Makoto M. Taketo, Ichiro Miyoshi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Transforming growth factor (TGF)-β receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Issue number1
Publication statusPublished - 1998 Jul 1


  • C57BL/6J mouse
  • Estrogen
  • Knockout mouse
  • Pituitary adenoma
  • Transforming growth factor-β
  • Transforming growth factor-β receptor type II


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