Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/-) knockout mice

Naoki Shida; Hidetoshi Ikeda; Takashi Yoshimoto; Masanobu Oshima; Makoto M. Taketo; Ichiro Miyoshi

doi:10.1016/S0925-4439(98)00024-6

Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/-) knockout mice

Naoki Shida, Hidetoshi Ikeda, Takashi Yoshimoto, Masanobu Oshima, Makoto M. Taketo, Ichiro Miyoshi

MED - Institute for Animal Experimentation

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Transforming growth factor (TGF)-β receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment. Copyright (C) 1998 Elsevier Science B.V.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1407
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4439(98)00024-6
Publication status	Published - 1998 Jul 1

Keywords

C57BL/6J mouse
Estrogen
Knockout mouse
Pituitary adenoma
Transforming growth factor-β
Transforming growth factor-β receptor type II

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10.1016/S0925-4439(98)00024-6

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AU - Taketo, Makoto M.

AU - Miyoshi, Ichiro

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Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/-) knockout mice

Abstract

Keywords

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