Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis

Keita Motonami; Taiichiro Watanabe; Jun Deguchi; Takafumi Fukushima; Hiroshi Tomita; Eriko Sugano; Manami Sato; Hiroyuki Kurino; Makoto Tamai; Mitsumasa Koyanagi

doi:10.1143/JJAP.45.3784

Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis

Keita Motonami, Taiichiro Watanabe, Jun Deguchi, Takafumi Fukushima, Hiroshi Tomita, Eriko Sugano, Manami Sato, Hiroyuki Kurino, Makoto Tamai, Mitsumasa Koyanagi

ENG - Mechanical Systems Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We have proposed a novel multilayer stacked retinal prosthesis chip based on three-dimensional integration technology. Implantable stimulus electrode arrays in polyimide flexible cables were fabricated for the electrical stimulation of the retina. To evaluate optimal retinal stimulus current, electrically evoked potential (EEP) was recorded in animal experiments using Japanese white rabbits. The EEP waveform was compared with visually evoked potential (VEP) waveform. The amplitude of the recorded EEP increased with stimulus current. The EEP waveform shows a similar behavior to the VEP waveform, indicating that the electrical stimulation of the retina can be exploited for the blind to perceive incident light to the retina.

Original language	English
Pages (from-to)	3784-3788
Number of pages	5
Journal	Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Volume	45
Issue number	4 B
DOIs	https://doi.org/10.1143/JJAP.45.3784
Publication status	Published - 2006 Apr 25

Keywords

Cable
Three-dimensional integration technology

ASJC Scopus subject areas

Engineering(all)
Physics and Astronomy(all)

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10.1143/JJAP.45.3784

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Motonami, K., Watanabe, T., Deguchi, J., Fukushima, T., Tomita, H., Sugano, E., Sato, M., Kurino, H., Tamai, M., & Koyanagi, M. (2006). Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis. Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, 45(4 B), 3784-3788. https://doi.org/10.1143/JJAP.45.3784

Motonami, K, Watanabe, T, Deguchi, J, Fukushima, T, Tomita, H, Sugano, E, Sato, M, Kurino, H, Tamai, M & Koyanagi, M 2006, 'Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis', Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, vol. 45, no. 4 B, pp. 3784-3788. https://doi.org/10.1143/JJAP.45.3784

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abstract = "We have proposed a novel multilayer stacked retinal prosthesis chip based on three-dimensional integration technology. Implantable stimulus electrode arrays in polyimide flexible cables were fabricated for the electrical stimulation of the retina. To evaluate optimal retinal stimulus current, electrically evoked potential (EEP) was recorded in animal experiments using Japanese white rabbits. The EEP waveform was compared with visually evoked potential (VEP) waveform. The amplitude of the recorded EEP increased with stimulus current. The EEP waveform shows a similar behavior to the VEP waveform, indicating that the electrical stimulation of the retina can be exploited for the blind to perceive incident light to the retina.",

keywords = "Cable, Three-dimensional integration technology",

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AU - Motonami, Keita

AU - Watanabe, Taiichiro

AU - Deguchi, Jun

AU - Fukushima, Takafumi

AU - Tomita, Hiroshi

AU - Sugano, Eriko

AU - Sato, Manami

AU - Kurino, Hiroyuki

AU - Tamai, Makoto

AU - Koyanagi, Mitsumasa

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Y1 - 2006/4/25

N2 - We have proposed a novel multilayer stacked retinal prosthesis chip based on three-dimensional integration technology. Implantable stimulus electrode arrays in polyimide flexible cables were fabricated for the electrical stimulation of the retina. To evaluate optimal retinal stimulus current, electrically evoked potential (EEP) was recorded in animal experiments using Japanese white rabbits. The EEP waveform was compared with visually evoked potential (VEP) waveform. The amplitude of the recorded EEP increased with stimulus current. The EEP waveform shows a similar behavior to the VEP waveform, indicating that the electrical stimulation of the retina can be exploited for the blind to perceive incident light to the retina.

AB - We have proposed a novel multilayer stacked retinal prosthesis chip based on three-dimensional integration technology. Implantable stimulus electrode arrays in polyimide flexible cables were fabricated for the electrical stimulation of the retina. To evaluate optimal retinal stimulus current, electrically evoked potential (EEP) was recorded in animal experiments using Japanese white rabbits. The EEP waveform was compared with visually evoked potential (VEP) waveform. The amplitude of the recorded EEP increased with stimulus current. The EEP waveform shows a similar behavior to the VEP waveform, indicating that the electrical stimulation of the retina can be exploited for the blind to perceive incident light to the retina.

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Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis

Abstract

Keywords

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