Evaluation of electrical stimulus current applied to retina cells for retinal prosthesis

Keita Motonami, Taiichiro Watanabe, Jun Deguchi, Takafumi Fukushima, Hiroshi Tomita, Eriko Sugano, Manami Sato, Hiroyuki Kurino, Makoto Tamai, Mitsumasa Koyanagi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We have proposed a novel multilayer stacked retinal prosthesis chip based on three-dimensional integration technology. Implantable stimulus electrode arrays in polyimide flexible cables were fabricated for the electrical stimulation of the retina. To evaluate optimal retinal stimulus current, electrically evoked potential (EEP) was recorded in animal experiments using Japanese white rabbits. The EEP waveform was compared with visually evoked potential (VEP) waveform. The amplitude of the recorded EEP increased with stimulus current. The EEP waveform shows a similar behavior to the VEP waveform, indicating that the electrical stimulation of the retina can be exploited for the blind to perceive incident light to the retina.

Original languageEnglish
Pages (from-to)3784-3788
Number of pages5
JournalJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Issue number4 B
Publication statusPublished - 2006 Apr 25


  • Cable
  • Three-dimensional integration technology

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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