Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure

Jiro Koyama; Jun Watanabe; Aki Yamada; Yoshito Koseki; Yuji Konno; Sunao Toda; Tsuyoshi Shinozaki; Masahito Miura; Mitsumasa Fukuchi; Mototsugu Ninomiya; Yutaka Kagaya; Kunio Shirato

doi:10.1253/circj.66.902

Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure

Jiro Koyama, Jun Watanabe, Aki Yamada, Yoshito Koseki, Yuji Konno, Sunao Toda, Tsuyoshi Shinozaki, Masahito Miura, Mitsumasa Fukuchi, Mototsugu Ninomiya, Yutaka Kagaya, Kunio Shirato

MED - Health Sciences

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

The significance of heart-rate turbulence (HRT) in patients with chronic heart failure (CHF) was evaluated to examine whether it is sensitive to the risk of ventricular tachycardia (VT). HRT is reported to predict the prognosis after myocardial infarction (MI), but its prognostic value in patients with CHF remains unknown. HRT was measured in 50 CHF patients (left ventricular ejection fraction <50% and/or left ventricular end-diastolic diameter >55mm, 34 cardiomyopathy, 16 post-MI) and 21 patients without obvious heart diseases (control). HRT slope and HRT onset were measured by the original definitions using digitized Holter ECG recordings. Cardiac pump function was assessed by echocardiography. The value of the HRT slope was significantly lower in CHF than in control (3.7±1.7 vs 16.4±5.3, mean±SD, p<0.01). The value of the HRT onset in patients with CHF was significantly higher than that in control patients (-1.1±1.9 vs -3.6±1.7, mean±SD, p<0.05). The HRT slope and onset in CHF patients with VT were nearly identical to those without VT. The HRT slope appears to be a powerful prognostic marker that shows significant differences between CHF subgroups when divided by clinical events; that is, CHF death and CHF hospitalization. However, it has limited value for predicting fatal ventricular arrhythmias.

Original language	English
Pages (from-to)	902-907
Number of pages	6
Journal	Circulation Journal
Volume	66
Issue number	10
DOIs	https://doi.org/10.1253/circj.66.902
Publication status	Published - 2002 Oct 1

Keywords

Heart rate variability
Late potential
SDNN
Sudden cardiac death
T wave alternans

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1253/circj.66.902

Cite this

@article{f4fb717dd685422a923b78e314a9e33b,

title = "Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure",

abstract = "The significance of heart-rate turbulence (HRT) in patients with chronic heart failure (CHF) was evaluated to examine whether it is sensitive to the risk of ventricular tachycardia (VT). HRT is reported to predict the prognosis after myocardial infarction (MI), but its prognostic value in patients with CHF remains unknown. HRT was measured in 50 CHF patients (left ventricular ejection fraction <50% and/or left ventricular end-diastolic diameter >55mm, 34 cardiomyopathy, 16 post-MI) and 21 patients without obvious heart diseases (control). HRT slope and HRT onset were measured by the original definitions using digitized Holter ECG recordings. Cardiac pump function was assessed by echocardiography. The value of the HRT slope was significantly lower in CHF than in control (3.7±1.7 vs 16.4±5.3, mean±SD, p<0.01). The value of the HRT onset in patients with CHF was significantly higher than that in control patients (-1.1±1.9 vs -3.6±1.7, mean±SD, p<0.05). The HRT slope and onset in CHF patients with VT were nearly identical to those without VT. The HRT slope appears to be a powerful prognostic marker that shows significant differences between CHF subgroups when divided by clinical events; that is, CHF death and CHF hospitalization. However, it has limited value for predicting fatal ventricular arrhythmias.",

keywords = "Heart rate variability, Late potential, SDNN, Sudden cardiac death, T wave alternans",

author = "Jiro Koyama and Jun Watanabe and Aki Yamada and Yoshito Koseki and Yuji Konno and Sunao Toda and Tsuyoshi Shinozaki and Masahito Miura and Mitsumasa Fukuchi and Mototsugu Ninomiya and Yutaka Kagaya and Kunio Shirato",

year = "2002",

month = oct,

day = "1",

doi = "10.1253/circj.66.902",

language = "English",

volume = "66",

pages = "902--907",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "10",

}

TY - JOUR

T1 - Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure

AU - Koyama, Jiro

AU - Watanabe, Jun

AU - Yamada, Aki

AU - Koseki, Yoshito

AU - Konno, Yuji

AU - Toda, Sunao

AU - Shinozaki, Tsuyoshi

AU - Miura, Masahito

AU - Fukuchi, Mitsumasa

AU - Ninomiya, Mototsugu

AU - Kagaya, Yutaka

AU - Shirato, Kunio

PY - 2002/10/1

Y1 - 2002/10/1

N2 - The significance of heart-rate turbulence (HRT) in patients with chronic heart failure (CHF) was evaluated to examine whether it is sensitive to the risk of ventricular tachycardia (VT). HRT is reported to predict the prognosis after myocardial infarction (MI), but its prognostic value in patients with CHF remains unknown. HRT was measured in 50 CHF patients (left ventricular ejection fraction <50% and/or left ventricular end-diastolic diameter >55mm, 34 cardiomyopathy, 16 post-MI) and 21 patients without obvious heart diseases (control). HRT slope and HRT onset were measured by the original definitions using digitized Holter ECG recordings. Cardiac pump function was assessed by echocardiography. The value of the HRT slope was significantly lower in CHF than in control (3.7±1.7 vs 16.4±5.3, mean±SD, p<0.01). The value of the HRT onset in patients with CHF was significantly higher than that in control patients (-1.1±1.9 vs -3.6±1.7, mean±SD, p<0.05). The HRT slope and onset in CHF patients with VT were nearly identical to those without VT. The HRT slope appears to be a powerful prognostic marker that shows significant differences between CHF subgroups when divided by clinical events; that is, CHF death and CHF hospitalization. However, it has limited value for predicting fatal ventricular arrhythmias.

AB - The significance of heart-rate turbulence (HRT) in patients with chronic heart failure (CHF) was evaluated to examine whether it is sensitive to the risk of ventricular tachycardia (VT). HRT is reported to predict the prognosis after myocardial infarction (MI), but its prognostic value in patients with CHF remains unknown. HRT was measured in 50 CHF patients (left ventricular ejection fraction <50% and/or left ventricular end-diastolic diameter >55mm, 34 cardiomyopathy, 16 post-MI) and 21 patients without obvious heart diseases (control). HRT slope and HRT onset were measured by the original definitions using digitized Holter ECG recordings. Cardiac pump function was assessed by echocardiography. The value of the HRT slope was significantly lower in CHF than in control (3.7±1.7 vs 16.4±5.3, mean±SD, p<0.01). The value of the HRT onset in patients with CHF was significantly higher than that in control patients (-1.1±1.9 vs -3.6±1.7, mean±SD, p<0.05). The HRT slope and onset in CHF patients with VT were nearly identical to those without VT. The HRT slope appears to be a powerful prognostic marker that shows significant differences between CHF subgroups when divided by clinical events; that is, CHF death and CHF hospitalization. However, it has limited value for predicting fatal ventricular arrhythmias.

KW - Heart rate variability

KW - Late potential

KW - SDNN

KW - Sudden cardiac death

KW - T wave alternans

UR - http://www.scopus.com/inward/record.url?scp=0036792425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036792425&partnerID=8YFLogxK

U2 - 10.1253/circj.66.902

DO - 10.1253/circj.66.902

M3 - Article

C2 - 12381082

AN - SCOPUS:0036792425

SN - 1346-9843

VL - 66

SP - 902

EP - 907

JO - Circulation Journal

JF - Circulation Journal

IS - 10

ER -

Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this