TY - JOUR
T1 - Evaluation of HER2 status in human breast carcinoma
AU - Suzuki, Takashi
AU - Tazawa, Chika
AU - Miura, Hiroshu
AU - Nakabayashi, Masao
AU - Moriya, Takuya
AU - Sasano, Hironobu
PY - 2003
Y1 - 2003
N2 - HER2 oncogene plays an important role in the oncogenesis and clinical behavior of 25-30% of human breast cancers. Recently, a recombinant humanized monoclonal antibody against HER2 pro- tein, trastuzumab, has been administrated to patients with HER2 positive breast carcinoma. This antibody-based therapy is only effective in HER2-positive carcinoma cases, and therefore, it is very important to evaluate HER2 status with accuracy in order to determine the appropriateness of trastuzumab treatment for the breast cancer patients. Evaluation of HER2 status is mainly performed in the primary breast tumor tissues and several pathological methods, including immunohistochemistry, fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH) which has been newly developed, are currently used in diagnostic laboratories. In this review, we describe the recent studies about these methods and discuss their reliability and possible further application to various pathological specimens obtained from breast carcinoma patients.
AB - HER2 oncogene plays an important role in the oncogenesis and clinical behavior of 25-30% of human breast cancers. Recently, a recombinant humanized monoclonal antibody against HER2 pro- tein, trastuzumab, has been administrated to patients with HER2 positive breast carcinoma. This antibody-based therapy is only effective in HER2-positive carcinoma cases, and therefore, it is very important to evaluate HER2 status with accuracy in order to determine the appropriateness of trastuzumab treatment for the breast cancer patients. Evaluation of HER2 status is mainly performed in the primary breast tumor tissues and several pathological methods, including immunohistochemistry, fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH) which has been newly developed, are currently used in diagnostic laboratories. In this review, we describe the recent studies about these methods and discuss their reliability and possible further application to various pathological specimens obtained from breast carcinoma patients.
KW - Breast carcinoma
KW - Chromogenic in situ hybridization (CISH)
KW - Fluorescence in situ hybridization (FISH)
KW - HER2
KW - Immunohistochemistry
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U2 - 10.1267/ahc.36.1
DO - 10.1267/ahc.36.1
M3 - Review article
AN - SCOPUS:0037660394
SN - 0044-5991
VL - 36
SP - 1
EP - 7
JO - Acta Histochemica et Cytochemica
JF - Acta Histochemica et Cytochemica
IS - 1
ER -
