Evaluation of O-[11C]methyl-L-tyrosine and O-[ 18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET

Kiichi Ishiwata; Kazunori Kawamura; Wei Fang Wang; Shozo Furumoto; Kazuo Kubota; Claudio Pascali; Anna Bogni; Ren Iwata

doi:10.1016/j.nucmedbio.2003.07.004

Evaluation of O-[¹¹C]methyl-L-tyrosine and O-[ ¹⁸F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET

Kiichi Ishiwata, Kazunori Kawamura, Wei Fang Wang, Shozo Furumoto, Kazuo Kubota, Claudio Pascali, Anna Bogni, Ren Iwata

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

We investigated the potential of O-[¹¹C]methyl-L-tyrosine and O-[¹⁸ F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[¹¹C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[ ¹⁸F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.

Original language	English
Pages (from-to)	191-198
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.nucmedbio.2003.07.004
Publication status	Published - 2004 Feb

Keywords

O-[C]methyl-L-tyrosine
O-[F]fluoromethyl-L- tyrosine
Positron emission tomography
Tumor imaging

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nucmedbio.2003.07.004

Cite this

@article{6b312cee2af34ba7898e0cf44f71786d,

title = "Evaluation of O-[11C]methyl-L-tyrosine and O-[ 18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET",

abstract = "We investigated the potential of O-[11C]methyl-L-tyrosine and O-[18 F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[11C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[ 18F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.",

keywords = "O-[C]methyl-L-tyrosine, O-[F]fluoromethyl-L- tyrosine, Positron emission tomography, Tumor imaging",

author = "Kiichi Ishiwata and Kazunori Kawamura and Wang, {Wei Fang} and Shozo Furumoto and Kazuo Kubota and Claudio Pascali and Anna Bogni and Ren Iwata",

note = "Funding Information: This work was partially supported by a Grant-in-Aid for Scientific Research No. 13470177 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.",

year = "2004",

month = feb,

doi = "10.1016/j.nucmedbio.2003.07.004",

language = "English",

volume = "31",

pages = "191--198",

journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",

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number = "2",

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T1 - Evaluation of O-[11C]methyl-L-tyrosine and O-[ 18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET

AU - Ishiwata, Kiichi

AU - Kawamura, Kazunori

AU - Wang, Wei Fang

AU - Furumoto, Shozo

AU - Kubota, Kazuo

AU - Pascali, Claudio

AU - Bogni, Anna

AU - Iwata, Ren

N1 - Funding Information: This work was partially supported by a Grant-in-Aid for Scientific Research No. 13470177 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2004/2

Y1 - 2004/2

N2 - We investigated the potential of O-[11C]methyl-L-tyrosine and O-[18 F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[11C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[ 18F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.

AB - We investigated the potential of O-[11C]methyl-L-tyrosine and O-[18 F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[11C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[ 18F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.

KW - O-[C]methyl-L-tyrosine

KW - O-[F]fluoromethyl-L- tyrosine

KW - Positron emission tomography

KW - Tumor imaging

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