Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit

Ai Otsuki; Takeo Otsuki; Hideki Tokunaga; Hitoshi Niikura; Satoru Nagase; Takashi Sugiyama; Masafumi Toyoshima; Hiroki Utsunomiya; Yoshihito Yokoyama; Hideki Mizunuma; Naoki Sato; Yukihiro Terada; Tadahiro Shoji; Toru Sugiyama; Kenji Nakahara; Tsuyoshi Ohta; Hidekazu Yamada; Toru Tase; Hiroshi Nishiyama; Keiya Fujimori; Tadao Takano; Fumiaki Takahashi; Yoh Watanabe; Nobuo Yaegashi

doi:10.1007/s10147-014-0732-0

Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit

Ai Otsuki, Takeo Otsuki, Hideki Tokunaga, Hitoshi Niikura, Satoru Nagase, Takashi Sugiyama, Masafumi Toyoshima, Hiroki Utsunomiya, Yoshihito Yokoyama, Hideki Mizunuma, Naoki Sato, Yukihiro Terada, Tadahiro Shoji, Toru Sugiyama, Kenji Nakahara, Tsuyoshi Ohta, Hidekazu Yamada, Toru Tase, Hiroshi Nishiyama, Keiya FujimoriTadao Takano, Fumiaki Takahashi, Yoh Watanabe, Nobuo Yaegashi

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma. Methods: We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit. Results: A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period. Conclusions: Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.

Original language	English
Pages (from-to)	574-578
Number of pages	5
Journal	International Journal of Clinical Oncology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s10147-014-0732-0
Publication status	Published - 2015 Jun 11

Keywords

Chemotherapy
Prognostic factor
Retrospective study
Uterine carcinosarcoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10147-014-0732-0

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Otsuki, A., Otsuki, T., Tokunaga, H., Niikura, H., Nagase, S., Sugiyama, T., Toyoshima, M., Utsunomiya, H., Yokoyama, Y., Mizunuma, H., Sato, N., Terada, Y., Shoji, T., Sugiyama, T., Nakahara, K., Ohta, T., Yamada, H., Tase, T., Nishiyama, H., ... Yaegashi, N. (2015). Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit. International Journal of Clinical Oncology, 20(3), 574-578. https://doi.org/10.1007/s10147-014-0732-0

@article{23054e4a0e374b71b86657b4ecd15abd,

title = "Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit",

abstract = "Background: The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma. Methods: We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit. Results: A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period. Conclusions: Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.",

keywords = "Chemotherapy, Prognostic factor, Retrospective study, Uterine carcinosarcoma",

author = "Ai Otsuki and Takeo Otsuki and Hideki Tokunaga and Hitoshi Niikura and Satoru Nagase and Takashi Sugiyama and Masafumi Toyoshima and Hiroki Utsunomiya and Yoshihito Yokoyama and Hideki Mizunuma and Naoki Sato and Yukihiro Terada and Tadahiro Shoji and Toru Sugiyama and Kenji Nakahara and Tsuyoshi Ohta and Hidekazu Yamada and Toru Tase and Hiroshi Nishiyama and Keiya Fujimori and Tadao Takano and Fumiaki Takahashi and Yoh Watanabe and Nobuo Yaegashi",

note = "Publisher Copyright: {\textcopyright} 2014, Japan Society of Clinical Oncology.",

year = "2015",

month = jun,

day = "11",

doi = "10.1007/s10147-014-0732-0",

language = "English",

volume = "20",

pages = "574--578",

journal = "International Journal of Clinical Oncology",

issn = "1341-9625",

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Otsuki, A, Otsuki, T, Tokunaga, H, Niikura, H, Nagase, S, Sugiyama, T, Toyoshima, M, Utsunomiya, H, Yokoyama, Y, Mizunuma, H, Sato, N, Terada, Y, Shoji, T, Sugiyama, T, Nakahara, K, Ohta, T, Yamada, H, Tase, T, Nishiyama, H, Fujimori, K, Takano, T, Takahashi, F, Watanabe, Y & Yaegashi, N 2015, 'Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit', International Journal of Clinical Oncology, vol. 20, no. 3, pp. 574-578. https://doi.org/10.1007/s10147-014-0732-0

TY - JOUR

T1 - Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma

T2 - a retrospective survey of the Tohoku Gynecologic Cancer Unit

AU - Otsuki, Ai

AU - Otsuki, Takeo

AU - Tokunaga, Hideki

AU - Niikura, Hitoshi

AU - Nagase, Satoru

AU - Sugiyama, Takashi

AU - Toyoshima, Masafumi

AU - Utsunomiya, Hiroki

AU - Yokoyama, Yoshihito

AU - Mizunuma, Hideki

AU - Sato, Naoki

AU - Terada, Yukihiro

AU - Shoji, Tadahiro

AU - Sugiyama, Toru

AU - Nakahara, Kenji

AU - Ohta, Tsuyoshi

AU - Yamada, Hidekazu

AU - Tase, Toru

AU - Nishiyama, Hiroshi

AU - Fujimori, Keiya

AU - Takano, Tadao

AU - Takahashi, Fumiaki

AU - Watanabe, Yoh

AU - Yaegashi, Nobuo

PY - 2015/6/11

Y1 - 2015/6/11

N2 - Background: The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma. Methods: We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit. Results: A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period. Conclusions: Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.

AB - Background: The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma. Methods: We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit. Results: A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period. Conclusions: Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.

KW - Chemotherapy

KW - Prognostic factor

KW - Retrospective study

KW - Uterine carcinosarcoma

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UR - http://www.scopus.com/inward/citedby.url?scp=84930576877&partnerID=8YFLogxK

U2 - 10.1007/s10147-014-0732-0

DO - 10.1007/s10147-014-0732-0

M3 - Article

C2 - 25030547

AN - SCOPUS:84930576877

SN - 1341-9625

VL - 20

SP - 574

EP - 578

JO - International Journal of Clinical Oncology

JF - International Journal of Clinical Oncology

IS - 3

ER -

Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit

Abstract

Keywords

UN SDGs

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