Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Masashi Koto; Azusa Hasegawa; Ryo Takagi; Hiroaki Ikawa; Kensuke Naganawa; Jun Etsu Mizoe; Keiichi Jingu; Hirohiko Tsujii; Hiroshi Tsuji; Tadashi Kamada; Yoshitaka Okamoto

doi:10.1002/hed.24397

Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Masashi Koto, Azusa Hasegawa, Ryo Takagi, Hiroaki Ikawa, Kensuke Naganawa, Jun Etsu Mizoe, Keiichi Jingu, Hirohiko Tsujii, Hiroshi Tsuji, Tadashi Kamada, Yoshitaka Okamoto

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Background Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced ACC of the tongue base. Methods Eighteen patients with ACC of the tongue base were treated with C-ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C-ion RT. Results The median follow-up period was 57 months (range, 10-132 months). The 5-year local control rate was 92%. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base. Conclusion C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base.

Original language	English
Pages (from-to)	E2122-E2126
Journal	Head and Neck
Volume	38
DOIs	https://doi.org/10.1002/hed.24397
Publication status	Published - 2016 Apr 1

Keywords

adenoid cystic carcinoma
carbon ion radiotherapy
head and neck cancer
radiotherapy
tongue base

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title = "Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base",

abstract = "Background Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced ACC of the tongue base. Methods Eighteen patients with ACC of the tongue base were treated with C-ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C-ion RT. Results The median follow-up period was 57 months (range, 10-132 months). The 5-year local control rate was 92%. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base. Conclusion C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base.",

keywords = "adenoid cystic carcinoma, carbon ion radiotherapy, head and neck cancer, radiotherapy, tongue base",

author = "Masashi Koto and Azusa Hasegawa and Ryo Takagi and Hiroaki Ikawa and Kensuke Naganawa and Mizoe, {Jun Etsu} and Keiichi Jingu and Hirohiko Tsujii and Hiroshi Tsuji and Tadashi Kamada and Yoshitaka Okamoto",

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doi = "10.1002/hed.24397",

language = "English",

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T1 - Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

AU - Koto, Masashi

AU - Hasegawa, Azusa

AU - Takagi, Ryo

AU - Ikawa, Hiroaki

AU - Naganawa, Kensuke

AU - Mizoe, Jun Etsu

AU - Jingu, Keiichi

AU - Tsujii, Hirohiko

AU - Tsuji, Hiroshi

AU - Kamada, Tadashi

AU - Okamoto, Yoshitaka

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced ACC of the tongue base. Methods Eighteen patients with ACC of the tongue base were treated with C-ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C-ion RT. Results The median follow-up period was 57 months (range, 10-132 months). The 5-year local control rate was 92%. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base. Conclusion C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base.

AB - Background Most cases of adenoid cystic carcinoma (ACC) of the tongue base are radioresistant, and are diagnosed in the advanced stage. Therefore, we evaluated the safety and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced ACC of the tongue base. Methods Eighteen patients with ACC of the tongue base were treated with C-ion RT between May 2002 and April 2014. Seventeen patients had T4a disease and 1 patient had T2 disease before C-ion RT. Results The median follow-up period was 57 months (range, 10-132 months). The 5-year local control rate was 92%. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 72% and 44%, respectively. Regarding late reactions, 2 patients developed grade 3 mandible osteoradionecrosis, and 1 had grade 3 hemorrhage of the tongue base. Conclusion C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base.

KW - adenoid cystic carcinoma

KW - carbon ion radiotherapy

KW - head and neck cancer

KW - radiotherapy

KW - tongue base

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Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Abstract

Keywords

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