Evidence for brain activation in patients with takotsubo cardiomyopathy

Hideaki Suzuki, Yasuharu Matsumoto, Tomohiro Kaneta, Koichiro Sugimura, Jun Takahashi, Yoshihiro Fukumoto, Shoki Takahashi, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)


Background: It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy. Methods and Results: We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using 99 mTc ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion. Conclusions: These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.

Original languageEnglish
Pages (from-to)256-258
Number of pages3
JournalCirculation Journal
Issue number1
Publication statusPublished - 2014


  • Brain
  • Stress
  • Takotsubo cardiomyopathy


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