Excessive lateral dental arch expansion in experimentally developed acromegaly-like rats

Masahiro Iikubo, Akane Kobayashi, Ikuho Kojima, Hidetoshi Ikeda, Maya Sakamoto, Takashi Sasano

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objective: To investigate morphological changes in the dental arches of acromegaly-like rats recently developed by means of exogenous IGF-I administration. Design: Human recombinant IGF-I (640 μg/day) was continuously administered subcutaneously for 4 weeks by osmotic mini-pumps to 10-week-old male rats (n = 6). Control animals were injected with saline alone (n = 6). After administration, all the rats were housed for 4 more weeks. Arch width (W), length (L) and angle (θ) in the mandible and maxilla were measured once a week during and after IGF-I administration. Results: The concentration of circulating IGF-I, and W and θ in the mandible were significantly increased as compared with the control rats. Although the mandibular dental arch stopped expanding once administration ended, it did not return to the control size. Conclusions: In our acromegaly-like rat model, mandibular dental arch growth is greater in the lateral than antero-posterior direction during and after IGF-I administration.

Original languageEnglish
Pages (from-to)924-927
Number of pages4
JournalArchives of Oral Biology
Issue number10
Publication statusPublished - 2008 Oct


  • Acromegaly
  • Dental arch
  • IGF-I
  • Morphologic change
  • Rat model


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