Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940

Noriaki Itagaki; Tsutomu Sugahara; Yoshiharu Iwabuchi

doi:10.1021/ol051570c

Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940

Noriaki Itagaki, Tsutomu Sugahara, Yoshiharu Iwabuchi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

(Chemical Equation Presented) A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retroaldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.

Original language	English
Pages (from-to)	4181-4183
Number of pages	3
Journal	Organic letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1021/ol051570c
Publication status	Published - 2005 Sept 15

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol051570c

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title = "Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940",

abstract = "(Chemical Equation Presented) A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retroaldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.",

author = "Noriaki Itagaki and Tsutomu Sugahara and Yoshiharu Iwabuchi",

year = "2005",

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doi = "10.1021/ol051570c",

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journal = "Organic Letters",

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AU - Itagaki, Noriaki

AU - Sugahara, Tsutomu

AU - Iwabuchi, Yoshiharu

PY - 2005/9/15

Y1 - 2005/9/15

N2 - (Chemical Equation Presented) A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retroaldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.

AB - (Chemical Equation Presented) A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retroaldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.

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JO - Organic Letters

JF - Organic Letters

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Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940

Abstract

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