Experience with carbon ion radiotherapy for WHO grade 2 diffuse astrocytomas

Azusa Hasegawa, Jun Etsu Mizoe, Hirohiko Tsujii, Tadashi Kamada, Keiichi Jingu, Yasuo Iwadate, Youichi Nakazato, Masao Matsutani, Kintomo Takakura

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Purpose: To assess outcomes of carbon ion radiotherapy for diffuse astrocytomas in adults. Methods and Materials: Between October 1994 and February 2002, 14 patients with diffuse astrocytoma, identified as eligible for carbon ion radiotherapy, were enrolled in a phase I/II clinical trial. Carbon ion radiotherapy was administered in 24 fractions over 6 weeks. The normal tissue morbidity was monitored carefully, and the carbon ion dose was escalated from 50.4 Gy equivalent (GyE) to 55.2 GyE. Patients were divided into two groups according to their carbon ion doses: a low-dose group in which 2 patients were irradiated with 46.2 GyE and 7 patients were irradiated with 50.4 GyE, and a high-dose group in which 5 patients were irradiated with 55.2 GyE. Results: Toxicities were within acceptable limits, and none of the patients developed Grade 3 or higher acute or late reactions. The median progression-free survival (PFS) time was 18 months for the low-dose group and 91 months for the high-dose group (p = 0.0030). The median overall survival (OS) time was 28 months for the low-dose group and not reached for the high-dose group (p = 0.0208). Conclusion: High-dose group patients showed significant improvement in PFS and OS rates compared to those in the low-dose group, and both dose groups showed acceptable toxicity.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number1
Publication statusPublished - 2012 May 1
Externally publishedYes


  • Carbon ion radiotherapy
  • Diffuse astrocytomas
  • Dose escalation study
  • High-LET radiotherapy
  • Phase I/II clinical trial

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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