Experimental pancreas imaging study with 13N-glutamate using positron computer tomography

Kazuo Kubota; Hiroshi Fukuda; Kenji Yamada; Satoshi Endo; Masatoshi Ito; Yoshinao Abe; Tatsuo Yamaguchi; Takehiko Fujiwara; Tachio Sato; Harutsugu Yamaura; Taiju Matsuzawa; Kiichiro Ishiwata; Ren Iwata; Tatsuo Ido

doi:10.1007/BF00251614

Experimental pancreas imaging study with ¹³N-glutamate using positron computer tomography

Kazuo Kubota, Hiroshi Fukuda, Kenji Yamada, Satoshi Endo, Masatoshi Ito, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Harutsugu Yamaura, Taiju Matsuzawa, Kiichiro Ishiwata, Ren Iwata, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

Abstract

Accumulation of ¹³N-l-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of ¹³N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with ¹³N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that ¹³N-glutamate was quite useful in positron imaging of the pancreas.

Original language	English
Pages (from-to)	528-530
Number of pages	3
Journal	European Journal of Nuclear Medicine
Volume	8
Issue number	12
DOIs	https://doi.org/10.1007/BF00251614
Publication status	Published - 1983 Dec
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/BF00251614

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title = "Experimental pancreas imaging study with 13N-glutamate using positron computer tomography",

abstract = "Accumulation of 13N-l-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.",

author = "Kazuo Kubota and Hiroshi Fukuda and Kenji Yamada and Satoshi Endo and Masatoshi Ito and Yoshinao Abe and Tatsuo Yamaguchi and Takehiko Fujiwara and Tachio Sato and Harutsugu Yamaura and Taiju Matsuzawa and Kiichiro Ishiwata and Ren Iwata and Tatsuo Ido",

year = "1983",

month = dec,

doi = "10.1007/BF00251614",

language = "English",

volume = "8",

pages = "528--530",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Verlag",

number = "12",

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TY - JOUR

T1 - Experimental pancreas imaging study with 13N-glutamate using positron computer tomography

AU - Kubota, Kazuo

AU - Fukuda, Hiroshi

AU - Yamada, Kenji

AU - Endo, Satoshi

AU - Ito, Masatoshi

AU - Abe, Yoshinao

AU - Yamaguchi, Tatsuo

AU - Fujiwara, Takehiko

AU - Sato, Tachio

AU - Yamaura, Harutsugu

AU - Matsuzawa, Taiju

AU - Ishiwata, Kiichiro

AU - Iwata, Ren

AU - Ido, Tatsuo

PY - 1983/12

Y1 - 1983/12

N2 - Accumulation of 13N-l-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.

AB - Accumulation of 13N-l-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.

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DO - 10.1007/BF00251614

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EP - 530

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

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ER -

Experimental pancreas imaging study with ¹³N-glutamate using positron computer tomography

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