Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

Satoru Goto; Takeshi Oshima; Katsuhisa Ikeda; Narihisa Ueda; Tomonori Takasaka

doi:10.1016/S0006-8993(97)00679-3

Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

Satoru Goto, Takeshi Oshima, Katsuhisa Ikeda, Narihisa Ueda, Tomonori Takasaka

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.

Original language	English
Pages (from-to)	324-326
Number of pages	3
Journal	Brain research
Volume	765
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(97)00679-3
Publication status	Published - 1997 Aug 15
Externally published	Yes

Keywords

Bumetanide- sensitive Na-K-2Cl cotransporter
Fibrocyte
Marginal cell
Spiral ligament
Stria vascularis

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)00679-3

Cite this

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title = "Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea",

abstract = "We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.",

keywords = "Bumetanide- sensitive Na-K-2Cl cotransporter, Fibrocyte, Marginal cell, Spiral ligament, Stria vascularis",

author = "Satoru Goto and Takeshi Oshima and Katsuhisa Ikeda and Narihisa Ueda and Tomonori Takasaka",

note = "Funding Information: This study was supported by the Uehara Memorial Foundation to K.I., Grant-in-Aid No. 08457447 to K.I., No. 40241608 to T.O., and No. 08407054 to T.T. from the Ministry of Education, Science and Culture of Japan.",

year = "1997",

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doi = "10.1016/S0006-8993(97)00679-3",

language = "English",

volume = "765",

pages = "324--326",

journal = "Molecular Brain Research",

issn = "0006-8993",

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number = "2",

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TY - JOUR

T1 - Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

AU - Goto, Satoru

AU - Oshima, Takeshi

AU - Ikeda, Katsuhisa

AU - Ueda, Narihisa

AU - Takasaka, Tomonori

N1 - Funding Information: This study was supported by the Uehara Memorial Foundation to K.I., Grant-in-Aid No. 08457447 to K.I., No. 40241608 to T.O., and No. 08407054 to T.T. from the Ministry of Education, Science and Culture of Japan.

PY - 1997/8/15

Y1 - 1997/8/15

N2 - We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.

AB - We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.

KW - Bumetanide- sensitive Na-K-2Cl cotransporter

KW - Fibrocyte

KW - Marginal cell

KW - Spiral ligament

KW - Stria vascularis

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DO - 10.1016/S0006-8993(97)00679-3

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AN - SCOPUS:0030883884

SN - 0006-8993

VL - 765

SP - 324

EP - 326

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 2

ER -

Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

Abstract

Keywords

ASJC Scopus subject areas

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