Expression of aryl hydrocarbon receptor in bone tissues

Yasuhiro Miki, Shuko Hata, Ryoko Saito, Katsuhiko Ono, Hironobu Sasano, Hiroyuki Kumamoto

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)


Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsive to environmental compounds such as dioxin. AhR signal has been known as xenobiotic receptor or xenobiotic sensor. Recently, the roles of AhR through the induction of cytokines come into focus. In bone tissues, AhR and its signaling pathway are detected in both osteoblasts and osteoclasts. In vitro and in vivo studies have been suggested that AhR signal mediates osteogenesis via cytokine signal in human bone as well as experimental animals. In this short review, we focused on the importance of AhR in bone and hard tissues.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Number of pages3
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
Publication statusPublished - 2012 Jan 1


  • Aryl hydrocarbon receptor
  • Dioxin
  • Osteoblast
  • Osteoclast
  • Osteogenesis


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