@article{46f19981356a40f685b4b18622f896d2,
title = "Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis: A Retrospective Cohort Study",
abstract = "Background: Bone morphogenetic protein-7 (BMP-7) is a signaling molecule belonging to the transforming growth factor-β superfamily. Recent studies have demonstrated that BMP-7 is expressed in various human cancers and plays an important role in the progression of their cancers. The purpose of this study was to investigate the clinicopathologic and prognostic impact of BMP-7 expression in clinical samples of non-small cell lung cancer. Methods: This study enrolled 160 patients with non-small cell lung cancer who underwent complete resection. Expression of BMP-7 in cancer tissue was evaluated by immunohistochemistry. Correlations between expression of BMP-7 and clinicopathologic factors and prognosis were analyzed. Results: In non-small cell lung cancer, BMP-7 expression was identified not only in cell membranes but also in the cytoplasm of cancer cells. Expression of BMP-7 correlated with p-T (P =.047), N factor (P =.013), and p-stage (P =.046). Overall survival rate was significantly lower in the BMP-7-positive group than in the BMP-7-negative group (P =.004). Multivariate analysis indicated that BMP-7 expression was one of the independent prognosis factors of overall survival (P =.021). Furthermore, among patients with postoperative recurrence (n = 58), the BMP-7-positive group (n = 29) had a significantly poorer prognosis than the BMP-7-negative group (n = 29) (P =.012). Conclusions: Expression of BMP-7 in non-small cell lung cancer was correlated with clinicopathologic factors and poorer prognosis. BMP-7 expression may be a useful predictor of aggressive activity of tumor behavior and postoperative outcome of patients with non-small cell lung cancer.",
keywords = "BMP-7, complete resection, lymph node metastasis, non-small cell lung cancer, prognosis",
author = "Masaya Aoki and Tadashi Umehara and Go Kamimura and Nobuhiro Imamura and Shoichiro Morizono and Yuto Nonaka and Takuya Tokunaga and Takeda, {Aya Harada} and Koki Maeda and Yui Watanabe and Toshiyuki Nagata and Tsunayuki Otsuka and Naoya Yokomakura and Kota Kariatsumari and Masakazu Yanagi and Masami Sato",
note = "Funding Information: Expression of BMP-7 in non-small cell lung cancer was correlated with clinicopathologic factors and poorer prognosis. BMP-7 expression may be a useful predictor of aggressive activity of tumor behavior and postoperative outcome of patients with non-small cell lung cancer. BMP-7 non-small cell lung cancer complete resection lymph node metastasis prognosis japan society for the promotion of science https://doi.org/10.13039/501100001691 [KAKENHI Grant Number 24791466]. cover-date January-December 2019 Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Japan Society for the Promotion of Science KAKENHI Grant Number 24791466. Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Author Contributions MA, KK, MY and MS contributed to the design of the study. MA, GK, NI, SM, YN, TT, AHT and KM contributed to data collection and data analysis. MA, TU, YW, TN, TO and NY contributed to statistical analysis. MA and TU contributed to writing of the study. All authors gave final approval for the publication of the study. ORCID iD Masaya Aoki https://orcid.org/0000-0003-1769-5382 Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2019",
doi = "10.1177/1179554919852087",
language = "English",
volume = "13",
journal = "Clinical Medicine Insights: Oncology",
issn = "1179-5549",
publisher = "Libertas Academica Ltd.",
}
