Expression of connexin 30 in the developing mouse cochlea

An Ping Xia; Yukio Katori; Takeshi Oshima; Kojiro Watanabe; Toshihiko Kikuchi; Katsuhisa Ikeda

doi:10.1016/S0006-8993(01)02216-8

Expression of connexin 30 in the developing mouse cochlea

An Ping Xia, Yukio Katori, Takeshi Oshima, Kojiro Watanabe, Toshihiko Kikuchi, Katsuhisa Ikeda

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Brain Research
Volume	898
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02216-8
Publication status	Published - 2001 Apr 20

Keywords

Connexin 30
Development
Endocochlear potential
Fibrocytes
RT-PCR

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10.1016/S0006-8993(01)02216-8

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title = "Expression of connexin 30 in the developing mouse cochlea",

abstract = "Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.",

keywords = "Connexin 30, Development, Endocochlear potential, Fibrocytes, RT-PCR",

author = "Xia, {An Ping} and Yukio Katori and Takeshi Oshima and Kojiro Watanabe and Toshihiko Kikuchi and Katsuhisa Ikeda",

note = "Funding Information: We wish to express our gratitude to Dr. Tomonori Takasaka for his valuable suggestions. This work was supported by a Grant-in-Aid for Science Research (No. 11557122 to K.I and No. 12770943 to Y.K.) from the Ministry of Education, Science and Culture, Japan.",

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AU - Xia, An Ping

AU - Katori, Yukio

AU - Oshima, Takeshi

AU - Watanabe, Kojiro

AU - Kikuchi, Toshihiko

AU - Ikeda, Katsuhisa

N1 - Funding Information: We wish to express our gratitude to Dr. Tomonori Takasaka for his valuable suggestions. This work was supported by a Grant-in-Aid for Science Research (No. 11557122 to K.I and No. 12770943 to Y.K.) from the Ministry of Education, Science and Culture, Japan.

PY - 2001/4/20

Y1 - 2001/4/20

N2 - Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.

AB - Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.

KW - Connexin 30

KW - Development

KW - Endocochlear potential

KW - Fibrocytes

KW - RT-PCR

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Expression of connexin 30 in the developing mouse cochlea

Abstract

Keywords

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