TY - JOUR
T1 - Expression of insulin-like growth factor 1 receptor in primary breast cancer
T2 - Immunohistochemical analysis
AU - Shimizu, Chikako
AU - Hasegawa, Tadashi
AU - Tani, Yoichi
AU - Takahashi, Fumiaki
AU - Takeuchi, Masahiro
AU - Watanabe, Toru
AU - Ando, Masashi
AU - Katsumata, Noriyuki
AU - Fujiwara, Yasuhiro
PY - 2004/12
Y1 - 2004/12
N2 - Insulin-like growth factor-1 receptor (IGF-1R) has been implicated in regulation in tumor growth. The results of previous studies performed by radioimmunoassay are conflicting, and the prognostic significance of IGF-1R expression in primary breast cancer is still controversial. IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody. The clinicopathologic variables and 5-year disease-free survival were studied, and their correlations between IGF-1R expressions were investigated. IGF-1R overexpression was observed in 43.8% of tumors. IGF-1R overexpression had no correlation with prognosis or with other clinicopathologic parameters, such as age, tumor size, nodal status, histologic grade, hormone receptor status, and human epidermal growth factor 2 status. Though its prognostic value in breast cancer is limited, immunohistochemical evaluation of IGF-1R by using this monoclonal antibody may be useful in translational research using archived material.
AB - Insulin-like growth factor-1 receptor (IGF-1R) has been implicated in regulation in tumor growth. The results of previous studies performed by radioimmunoassay are conflicting, and the prognostic significance of IGF-1R expression in primary breast cancer is still controversial. IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody. The clinicopathologic variables and 5-year disease-free survival were studied, and their correlations between IGF-1R expressions were investigated. IGF-1R overexpression was observed in 43.8% of tumors. IGF-1R overexpression had no correlation with prognosis or with other clinicopathologic parameters, such as age, tumor size, nodal status, histologic grade, hormone receptor status, and human epidermal growth factor 2 status. Though its prognostic value in breast cancer is limited, immunohistochemical evaluation of IGF-1R by using this monoclonal antibody may be useful in translational research using archived material.
KW - ER
KW - HER2
KW - IGF-1R
KW - IGF-binding proteins
KW - IGFBPs
KW - Insulin-like growth factor 1 receptor
KW - PR
KW - estrogen receptor
KW - immunohistochemistry
KW - insulin-like growth factor-1 receptor
KW - primary breast cancer
KW - progesterone receptor
KW - prognostic marker
UR - http://www.scopus.com/inward/record.url?scp=10944249457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10944249457&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2004.09.005
DO - 10.1016/j.humpath.2004.09.005
M3 - Article
C2 - 15619214
AN - SCOPUS:10944249457
SN - 0046-8177
VL - 35
SP - 1537
EP - 1542
JO - Human Pathology
JF - Human Pathology
IS - 12
ER -
