TY - JOUR
T1 - Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells
AU - Yamaguchi, Yasuka L.
AU - Tanaka, Satomi S.
AU - Kasa, Miyuki
AU - Yasuda, Kunio
AU - Tam, Patrick P.L.
AU - Matsui, Yasuhisa
PY - 2006/8
Y1 - 2006/8
N2 - The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells.
AB - The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells.
KW - Germ cells
KW - Low density lipoprotein receptor-related protein 4
KW - Lrp4
KW - Mouse
KW - PGCs
UR - http://www.scopus.com/inward/record.url?scp=33646770321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646770321&partnerID=8YFLogxK
U2 - 10.1016/j.modgep.2005.11.013
DO - 10.1016/j.modgep.2005.11.013
M3 - Article
C2 - 16434236
AN - SCOPUS:33646770321
SN - 1567-133X
VL - 6
SP - 607
EP - 612
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 6
ER -