TY - JOUR
T1 - Expression of organic anion transporting polypeptide E (OATP-E) in human placenta
AU - Sato, K.
AU - Sugawara, J.
AU - Sato, T.
AU - Mizutamari, H.
AU - Suzuki, T.
AU - Ito, A.
AU - Mikkaichi, T.
AU - Onogawa, T.
AU - Tanemoto, M.
AU - Unno, M.
AU - Abe, T.
AU - Okamura, K.
N1 - Funding Information:
This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan, the Inamori Foundation, the Japan Research Foundation for Clinical Pharmacology, the Kowa Foundation, the Nishimiya Foundation, the Ono Medical Research Foundation, the Suzuken Memorial Foundation, the Tokyo Biochemical Research Foundation, the Uehara Memorial Foundation and the Yamanouchi Foundation for Research on Metabolic Disorders.
PY - 2003
Y1 - 2003
N2 - Purpose: To examine the expression of multifunctional Na+-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta. Methods: Western blot analysis was performed using a specific antibody against OATP-E in human placenta to confirm the expression of OATP-E at the protein level. Immunohistochemistry was also performed using the specific antibody against OATP-E on frozen sections of human placenta. Results: By Western blot analysis, a single band for OATP-E was observed in human placenta. Immunohistochemistry revealed that OATP-E was predominantly expressed at the apical surface of the syncytiotrophoblasts in placenta. Conclusion: These results reveal that OATP-E is expressed in human placenta, suggesting a functional role for the transplacental transter of thyroid hormone.
AB - Purpose: To examine the expression of multifunctional Na+-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta. Methods: Western blot analysis was performed using a specific antibody against OATP-E in human placenta to confirm the expression of OATP-E at the protein level. Immunohistochemistry was also performed using the specific antibody against OATP-E on frozen sections of human placenta. Results: By Western blot analysis, a single band for OATP-E was observed in human placenta. Immunohistochemistry revealed that OATP-E was predominantly expressed at the apical surface of the syncytiotrophoblasts in placenta. Conclusion: These results reveal that OATP-E is expressed in human placenta, suggesting a functional role for the transplacental transter of thyroid hormone.
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U2 - 10.1053/plac.2002.0907
DO - 10.1053/plac.2002.0907
M3 - Article
C2 - 12566240
AN - SCOPUS:0037586412
SN - 0143-4004
VL - 24
SP - 144
EP - 148
JO - Placenta
JF - Placenta
IS - 2-3
ER -