Expression of organic anion transporting polypeptide E (OATP-E) in human placenta

K. Sato, J. Sugawara, T. Sato, H. Mizutamari, T. Suzuki, A. Ito, T. Mikkaichi, T. Onogawa, M. Tanemoto, M. Unno, T. Abe, K. Okamura

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


Purpose: To examine the expression of multifunctional Na+-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta. Methods: Western blot analysis was performed using a specific antibody against OATP-E in human placenta to confirm the expression of OATP-E at the protein level. Immunohistochemistry was also performed using the specific antibody against OATP-E on frozen sections of human placenta. Results: By Western blot analysis, a single band for OATP-E was observed in human placenta. Immunohistochemistry revealed that OATP-E was predominantly expressed at the apical surface of the syncytiotrophoblasts in placenta. Conclusion: These results reveal that OATP-E is expressed in human placenta, suggesting a functional role for the transplacental transter of thyroid hormone.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
Issue number2-3
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology


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