Expression of the pre-S(2) gene of hepatitis B virus in Escherichia coli

K. Tachibana, M. Imai, H. Okamoto, K. Yoda, H. Kadokura, Y. Katayama, M. Yamasaki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The pre-S(2) antigen of hepatitis B virus was produced as a fused protein with the E.coli alkaline phosphatase. The product remained in precipitable materials but could be solubilized by 8M urea treatment. The amount of the bacterial antigen was equivalent to 160 μg of serum HBsAg per ml of culture.

Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalBiotechnology Letters
Volume8
Issue number10
DOIs
Publication statusPublished - 1986 Oct

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