Extraadrenal Immunohistochemical Distribution of Steroid 21-Hydroxylase in Human

Hironobu Sasano, Nobuaki Sasano

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5 Citations (Scopus)


Using an antibody against cytochrome P-450 specific for steroid 21-hydroxylase (P-45OC21), extraadrenal distribution and localization of the enzyme were immunohistochemically examined on various normal human tissues. Immunoreactive P-450C21 was demonstrated in the renal tubular system, especially in distal tubules and cortical and medullary collecting tubules : excretory ducts including intercalated ducts of the pancreas and salivary glands ; secretory ducts of the mammary glands. The immunoreactivity for P-450C21 was not present in the colon and liver. Transepithelial transport of sodium, potassium and hydrogen ions occurs in those sites where P-450C21 is present and mineralocorticoid receptors are presumed to be present. Relationship of extraadrenal 21-hydroxylase, which produces deoxycorticosterone locally, to a mineralocorticoid action is proposed.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
Journalthe tohoku journal of experimental medicine
Issue number1
Publication statusPublished - 1988


  • P-45O
  • extraadrenal tissues
  • immunohistochemistry
  • mineralocorticoid action

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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