Eye-head coordination abnormalities and regional cerebral blood flow in Alzheimer's disease

Nakano Norihito; Hatakeyama Yoshihisa; Fukatsu Ryo; Hayashi Shuichiro; Fujii Mitsuru; Fujimori Kenji; Takahata Naohiko

doi:10.1016/S0278-5846(99)00054-8

Eye-head coordination abnormalities and regional cerebral blood flow in Alzheimer's disease

Nakano Norihito, Hatakeyama Yoshihisa, Fukatsu Ryo, Hayashi Shuichiro, Fujii Mitsuru, Fujimori Kenji, Takahata Naohiko

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

1. Three patients with Alzheimer's disease (AD) and three healthy controls (HC) were examined for eye-head coordination. Regional cerebral blood flow (rCBF) was measured in AD patients. 2. Eye-head coordination was analyzed using a Vision analyzer, and magnetic sensors. The authors measured the rCBF with ¹²³I-IMP, and ^99mTc-ECD SPECT. 3. AD reduced gaze accuracy and head movements, and prolonged the latency of saccade as compared to HC. AD patients had a tendency to focus on the target by using eye movements only. 4. AD reduced the rCBF in the inferior parietal part and the visual area, relative to the motor area. Damage of these areas may have caused the eye-head coordination disorders in the AD patients.

Original language	English
Pages (from-to)	1053-1062
Number of pages	10
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/S0278-5846(99)00054-8
Publication status	Published - 1999 Aug 1
Externally published	Yes

Keywords

Alzheimer's disease
Cerebral blood flow
Eye movement
Eye-head coordination

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/S0278-5846(99)00054-8

Cite this

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title = "Eye-head coordination abnormalities and regional cerebral blood flow in Alzheimer's disease",

abstract = "1. Three patients with Alzheimer's disease (AD) and three healthy controls (HC) were examined for eye-head coordination. Regional cerebral blood flow (rCBF) was measured in AD patients. 2. Eye-head coordination was analyzed using a Vision analyzer, and magnetic sensors. The authors measured the rCBF with 123I-IMP, and 99mTc-ECD SPECT. 3. AD reduced gaze accuracy and head movements, and prolonged the latency of saccade as compared to HC. AD patients had a tendency to focus on the target by using eye movements only. 4. AD reduced the rCBF in the inferior parietal part and the visual area, relative to the motor area. Damage of these areas may have caused the eye-head coordination disorders in the AD patients.",

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AU - Norihito, Nakano

AU - Yoshihisa, Hatakeyama

AU - Ryo, Fukatsu

AU - Shuichiro, Hayashi

AU - Mitsuru, Fujii

AU - Kenji, Fujimori

AU - Naohiko, Takahata

PY - 1999/8/1

Y1 - 1999/8/1

N2 - 1. Three patients with Alzheimer's disease (AD) and three healthy controls (HC) were examined for eye-head coordination. Regional cerebral blood flow (rCBF) was measured in AD patients. 2. Eye-head coordination was analyzed using a Vision analyzer, and magnetic sensors. The authors measured the rCBF with 123I-IMP, and 99mTc-ECD SPECT. 3. AD reduced gaze accuracy and head movements, and prolonged the latency of saccade as compared to HC. AD patients had a tendency to focus on the target by using eye movements only. 4. AD reduced the rCBF in the inferior parietal part and the visual area, relative to the motor area. Damage of these areas may have caused the eye-head coordination disorders in the AD patients.

AB - 1. Three patients with Alzheimer's disease (AD) and three healthy controls (HC) were examined for eye-head coordination. Regional cerebral blood flow (rCBF) was measured in AD patients. 2. Eye-head coordination was analyzed using a Vision analyzer, and magnetic sensors. The authors measured the rCBF with 123I-IMP, and 99mTc-ECD SPECT. 3. AD reduced gaze accuracy and head movements, and prolonged the latency of saccade as compared to HC. AD patients had a tendency to focus on the target by using eye movements only. 4. AD reduced the rCBF in the inferior parietal part and the visual area, relative to the motor area. Damage of these areas may have caused the eye-head coordination disorders in the AD patients.

KW - Alzheimer's disease

KW - Cerebral blood flow

KW - Eye movement

KW - Eye-head coordination

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Eye-head coordination abnormalities and regional cerebral blood flow in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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