Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

Ting ting Li; Tomoya Inose; Takahiro Oikawa; Masayuki Tokunaga; Keiichiro Hatoyama; Kouichi Nakashima; Takashi Kamei; Kohsuke Gonda; Yoshio Kobayashi

doi:10.1080/10667857.2018.1502504

Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

Ting ting Li, Tomoya Inose, Takahiro Oikawa, Masayuki Tokunaga, Keiichiro Hatoyama, Kouichi Nakashima, Takashi Kamei, Kohsuke Gonda, Yoshio Kobayashi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO₂, large Au nanoparticles (Au^L), and small Au nanoparticles (Au^S). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO₂). Au^L and Au^S were fabricated by reducing Au³⁺ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO₂ surface by using (3-aminopropyl)-triethoxysilane (QD/SiO₂/NH₂). Both Au^L and Au^S were immobilized on QD/SiO₂/NH₂ by successively reacting Au^L and Au^S with QD/SiO₂/NH₂ (QD/SiO₂/NH₂/Au^L/Au^S). Surface modification of QD/SiO₂/NH₂/Au^L/Au^S was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO₂/NH₂/Au^L/Au^S/PEG). The QD/SiO₂/NH₂/Au^L/Au^S/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 10⁴ HU/M. The QD/SiO₂/NH₂/Au^L/Au^S/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen.

Original language	English
Pages (from-to)	737-747
Number of pages	11
Journal	Materials Technology
Volume	33
Issue number	11
DOIs	https://doi.org/10.1080/10667857.2018.1502504
Publication status	Published - 2018 Sept 19

Keywords

Quantum dot
X-ray imaging
core-shell
fluorescence imaging
gold
nanoparticle
silica-coating

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10.1080/10667857.2018.1502504

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@article{7114f31495ba44f9b3b4cae009f28522,

title = "Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles",

abstract = "The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (AuL), and small Au nanoparticles (AuS). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2). AuL and AuS were fabricated by reducing Au3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2/NH2). Both AuL and AuS were immobilized on QD/SiO2/NH2 by successively reacting AuL and AuS with QD/SiO2/NH2 (QD/SiO2/NH2/AuL/AuS). Surface modification of QD/SiO2/NH2/AuL/AuS was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2/NH2/AuL/AuS/PEG). The QD/SiO2/NH2/AuL/AuS/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 104 HU/M. The QD/SiO2/NH2/AuL/AuS/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen.",

keywords = "Quantum dot, X-ray imaging, core-shell, fluorescence imaging, gold, nanoparticle, silica-coating",

author = "Li, {Ting ting} and Tomoya Inose and Takahiro Oikawa and Masayuki Tokunaga and Keiichiro Hatoyama and Kouichi Nakashima and Takashi Kamei and Kohsuke Gonda and Yoshio Kobayashi",

note = "Funding Information: This work was supported by the JSPS KAKENHI [24310085]; Grant-in-Aid for A3 Foresight Program from JSPS;JSPS KAKENHI [16K15572];JSPS KAKENHI [16H05168]; Funding Information: This work was supported by JSPS KAKENHI Grant Numbers 24310085, 16H05168, and 16K15572 and Grant-in-Aid for A3 Foresight Program from JSPS. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

month = sep,

day = "19",

doi = "10.1080/10667857.2018.1502504",

language = "English",

volume = "33",

pages = "737--747",

journal = "Materials Technology",

issn = "1066-7857",

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T1 - Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

AU - Li, Ting ting

AU - Inose, Tomoya

AU - Oikawa, Takahiro

AU - Tokunaga, Masayuki

AU - Hatoyama, Keiichiro

AU - Nakashima, Kouichi

AU - Kamei, Takashi

AU - Gonda, Kohsuke

AU - Kobayashi, Yoshio

N1 - Funding Information: This work was supported by the JSPS KAKENHI [24310085]; Grant-in-Aid for A3 Foresight Program from JSPS;JSPS KAKENHI [16K15572];JSPS KAKENHI [16H05168]; Funding Information: This work was supported by JSPS KAKENHI Grant Numbers 24310085, 16H05168, and 16K15572 and Grant-in-Aid for A3 Foresight Program from JSPS. Publisher Copyright: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2018/9/19

Y1 - 2018/9/19

N2 - The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (AuL), and small Au nanoparticles (AuS). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2). AuL and AuS were fabricated by reducing Au3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2/NH2). Both AuL and AuS were immobilized on QD/SiO2/NH2 by successively reacting AuL and AuS with QD/SiO2/NH2 (QD/SiO2/NH2/AuL/AuS). Surface modification of QD/SiO2/NH2/AuL/AuS was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2/NH2/AuL/AuS/PEG). The QD/SiO2/NH2/AuL/AuS/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 104 HU/M. The QD/SiO2/NH2/AuL/AuS/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen.

AB - The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (AuL), and small Au nanoparticles (AuS). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2). AuL and AuS were fabricated by reducing Au3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2/NH2). Both AuL and AuS were immobilized on QD/SiO2/NH2 by successively reacting AuL and AuS with QD/SiO2/NH2 (QD/SiO2/NH2/AuL/AuS). Surface modification of QD/SiO2/NH2/AuL/AuS was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2/NH2/AuL/AuS/PEG). The QD/SiO2/NH2/AuL/AuS/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au (M) was 1.2 × 104 HU/M. The QD/SiO2/NH2/AuL/AuS/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen.

KW - Quantum dot

KW - X-ray imaging

KW - core-shell

KW - fluorescence imaging

KW - gold

KW - nanoparticle

KW - silica-coating

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DO - 10.1080/10667857.2018.1502504

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AN - SCOPUS:85051727965

SN - 1066-7857

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SP - 737

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JO - Materials Technology

JF - Materials Technology

IS - 11

ER -

Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

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Keywords

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