TY - JOUR
T1 - Fabrication and evaluation of ascorbic acid phosphate-loaded spherical porous hydroxyapatite/octacalcium phosphate granules
AU - Kamitakahara, Masanobu
AU - Ishii, Airi
AU - Matsubara, Hideaki
AU - Kawashita, Masakazu
AU - Furuya, Maiko
AU - Kanetaka, Hiroyasu
N1 - Funding Information:
Acknowledgements This work was partly supported by the Program for Creation of Interdisciplinary Research of the Frontier Research Institute for Interdisciplinary Sciences, Tohoku University and the MIKIYA Science and Technology Foundation. This work was also partly supported by KAKENHI19H04462. The authors thank Mr. Takashina of the Technical Division, School of Engineering, Tohoku University for experimental help in the FT-IR measurements.
Publisher Copyright:
© 2021 The Ceramic Society of Japan. All rights reserved.
PY - 2021/1
Y1 - 2021/1
N2 - The spherical porous granules of octacalcium phosphate (OCP) and hydroxyapatite (HA) have the potential for applications in scaffolds for bone regeneration. The spherical porous alpha-tricalcium phosphate granules were immersed in a pH 5.0 buffer solution that contained 0.1 mM of ascorbic acid phosphate (AscP), an osteogenesis-promoting drug, at 60 °C. This resulted in the fabrication of the AscP-loaded spherical porous HA/OCP granules. The OCP and HA phases were concentrated at the surface and interior of the granules, respectively. Furthermore, the HA/OCP core/shell-like structure of the granules was observed for the first time. The loaded AscP in the HA/OCP granules was slowly released in a pH 7.4 buffer solution. The differentiation of the osteoblast-like cells was promoted by the AscP-loaded HA/OCP granules. These granules possessed the potential for applications in artificial bones to promote bone regeneration.
AB - The spherical porous granules of octacalcium phosphate (OCP) and hydroxyapatite (HA) have the potential for applications in scaffolds for bone regeneration. The spherical porous alpha-tricalcium phosphate granules were immersed in a pH 5.0 buffer solution that contained 0.1 mM of ascorbic acid phosphate (AscP), an osteogenesis-promoting drug, at 60 °C. This resulted in the fabrication of the AscP-loaded spherical porous HA/OCP granules. The OCP and HA phases were concentrated at the surface and interior of the granules, respectively. Furthermore, the HA/OCP core/shell-like structure of the granules was observed for the first time. The loaded AscP in the HA/OCP granules was slowly released in a pH 7.4 buffer solution. The differentiation of the osteoblast-like cells was promoted by the AscP-loaded HA/OCP granules. These granules possessed the potential for applications in artificial bones to promote bone regeneration.
KW - Artificial bone
KW - Ascorbic acid
KW - Core/shell structure
KW - Hydroxyapatite
KW - Key-words: Octacalcium phosphate
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U2 - 10.2109/jcersj2.20170
DO - 10.2109/jcersj2.20170
M3 - Article
AN - SCOPUS:85098795251
SN - 1882-0743
VL - 129
SP - 60
EP - 65
JO - Journal of the Ceramic Society of Japan
JF - Journal of the Ceramic Society of Japan
IS - 1
ER -