Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties

M. Tayama; T. Inose; N. Yamauchi; K. Nakashima; M. Tokunaga; C. Kato; K. Gonda; Y. Kobayashi

doi:10.1080/02726351.2021.1934918

Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties

M. Tayama, T. Inose, N. Yamauchi, K. Nakashima, M. Tokunaga, C. Kato, K. Gonda, Y. Kobayashi

MED - Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

This work describes the fabrication of quantum dot (QD)/silica (SiO₂) core–shell particles immobilized with Au nanoparticles and the evaluation of their abilities in fluorescence and x-ray computed tomography (CT) imaging. The QD nanoparticles were coated with silica shells by a sol-gel method using tetraethyl orthosilicate (QD/SiO₂). Reduction of Au³⁺ in a citrate aqueous solution gave an Au nanoparticle colloidal solution. (3-Mercaptopropyl)trimethoxysilane thiolated the QD/SiO₂ particle surface (QD/SiO₂/SH). Immobilization of the Au nanoparticles on the QD/SiO₂/SH particle surface was performed with the addition of the Au nanoparticle colloidal solution to the QD/SiO₂/SH nanoparticle colloidal solution (QD/SiO₂/SH/Au). Surface-PEGylated QD/SiO₂/SH/Au particles were fabricated using thiol-terminated polyethylene glycol (PEG) (QD/SiO₂/SH/Au/PEG). The QD/SiO₂/SH/Au/PEG nanoparticle colloidal solution was imaged by fluorescence and x-ray CT imaging techniques. The CT value per unit concentration of Au (M) for the QD/SiO₂/SH/Au/PEG nanoparticle colloidal solution was 1.5 × 10⁴ HU/M. The QD/SiO₂/SH/Au/PEG nanoparticle colloidal solution was injected into the tail vein of a mouse and circulated in the blood, although some QD/SiO₂/SH/Au/PEG nanoparticles were trapped and remained in the liver and spleen.

Original language	English
Pages (from-to)	252-260
Number of pages	9
Journal	Particulate Science and Technology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1080/02726351.2021.1934918
Publication status	Published - 2022

Keywords

Quantum dot
core–shell
fluorescence imaging
gold
nanoparticle
silica-coating
x-ray imaging

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10.1080/02726351.2021.1934918

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title = "Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties",

abstract = "This work describes the fabrication of quantum dot (QD)/silica (SiO2) core–shell particles immobilized with Au nanoparticles and the evaluation of their abilities in fluorescence and x-ray computed tomography (CT) imaging. The QD nanoparticles were coated with silica shells by a sol-gel method using tetraethyl orthosilicate (QD/SiO2). Reduction of Au3+ in a citrate aqueous solution gave an Au nanoparticle colloidal solution. (3-Mercaptopropyl)trimethoxysilane thiolated the QD/SiO2 particle surface (QD/SiO2/SH). Immobilization of the Au nanoparticles on the QD/SiO2/SH particle surface was performed with the addition of the Au nanoparticle colloidal solution to the QD/SiO2/SH nanoparticle colloidal solution (QD/SiO2/SH/Au). Surface-PEGylated QD/SiO2/SH/Au particles were fabricated using thiol-terminated polyethylene glycol (PEG) (QD/SiO2/SH/Au/PEG). The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was imaged by fluorescence and x-ray CT imaging techniques. The CT value per unit concentration of Au (M) for the QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was 1.5 × 104 HU/M. The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was injected into the tail vein of a mouse and circulated in the blood, although some QD/SiO2/SH/Au/PEG nanoparticles were trapped and remained in the liver and spleen.",

keywords = "Quantum dot, core–shell, fluorescence imaging, gold, nanoparticle, silica-coating, x-ray imaging",

author = "M. Tayama and T. Inose and N. Yamauchi and K. Nakashima and M. Tokunaga and C. Kato and K. Gonda and Y. Kobayashi",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2022",

doi = "10.1080/02726351.2021.1934918",

language = "English",

volume = "40",

pages = "252--260",

journal = "Particulate Science and Technology",

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T1 - Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties

AU - Tayama, M.

AU - Inose, T.

AU - Yamauchi, N.

AU - Nakashima, K.

AU - Tokunaga, M.

AU - Kato, C.

AU - Gonda, K.

AU - Kobayashi, Y.

PY - 2022

Y1 - 2022

N2 - This work describes the fabrication of quantum dot (QD)/silica (SiO2) core–shell particles immobilized with Au nanoparticles and the evaluation of their abilities in fluorescence and x-ray computed tomography (CT) imaging. The QD nanoparticles were coated with silica shells by a sol-gel method using tetraethyl orthosilicate (QD/SiO2). Reduction of Au3+ in a citrate aqueous solution gave an Au nanoparticle colloidal solution. (3-Mercaptopropyl)trimethoxysilane thiolated the QD/SiO2 particle surface (QD/SiO2/SH). Immobilization of the Au nanoparticles on the QD/SiO2/SH particle surface was performed with the addition of the Au nanoparticle colloidal solution to the QD/SiO2/SH nanoparticle colloidal solution (QD/SiO2/SH/Au). Surface-PEGylated QD/SiO2/SH/Au particles were fabricated using thiol-terminated polyethylene glycol (PEG) (QD/SiO2/SH/Au/PEG). The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was imaged by fluorescence and x-ray CT imaging techniques. The CT value per unit concentration of Au (M) for the QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was 1.5 × 104 HU/M. The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was injected into the tail vein of a mouse and circulated in the blood, although some QD/SiO2/SH/Au/PEG nanoparticles were trapped and remained in the liver and spleen.

AB - This work describes the fabrication of quantum dot (QD)/silica (SiO2) core–shell particles immobilized with Au nanoparticles and the evaluation of their abilities in fluorescence and x-ray computed tomography (CT) imaging. The QD nanoparticles were coated with silica shells by a sol-gel method using tetraethyl orthosilicate (QD/SiO2). Reduction of Au3+ in a citrate aqueous solution gave an Au nanoparticle colloidal solution. (3-Mercaptopropyl)trimethoxysilane thiolated the QD/SiO2 particle surface (QD/SiO2/SH). Immobilization of the Au nanoparticles on the QD/SiO2/SH particle surface was performed with the addition of the Au nanoparticle colloidal solution to the QD/SiO2/SH nanoparticle colloidal solution (QD/SiO2/SH/Au). Surface-PEGylated QD/SiO2/SH/Au particles were fabricated using thiol-terminated polyethylene glycol (PEG) (QD/SiO2/SH/Au/PEG). The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was imaged by fluorescence and x-ray CT imaging techniques. The CT value per unit concentration of Au (M) for the QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was 1.5 × 104 HU/M. The QD/SiO2/SH/Au/PEG nanoparticle colloidal solution was injected into the tail vein of a mouse and circulated in the blood, although some QD/SiO2/SH/Au/PEG nanoparticles were trapped and remained in the liver and spleen.

KW - Quantum dot

KW - core–shell

KW - fluorescence imaging

KW - gold

KW - nanoparticle

KW - silica-coating

KW - x-ray imaging

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U2 - 10.1080/02726351.2021.1934918

DO - 10.1080/02726351.2021.1934918

M3 - Article

AN - SCOPUS:85107688165

SN - 0272-6351

VL - 40

SP - 252

EP - 260

JO - Particulate Science and Technology

JF - Particulate Science and Technology

IS - 2

ER -

Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties

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Keywords

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