Fabrication of pure nanodrugs of podophyllotoxin dimer and their anticancer activity

Yoshikazu Ikuta; Yoshitaka Koseki; Tatsuya Murakami; Minoru Ueda; Hidetoshi Oikawa; Hitoshi Kasai

doi:10.1246/cl.130224

Fabrication of pure nanodrugs of podophyllotoxin dimer and their anticancer activity

Yoshikazu Ikuta, Yoshitaka Koseki, Tatsuya Murakami, Minoru Ueda, Hidetoshi Oikawa, Hitoshi Kasai

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Drug nanoparticles of water-insoluble bioactive compounds are potentially applicable in next-generation drug delivery systems (DDSs). As an example of such nanoparticles, the dimeric podophyllotoxin (PPT) was synthesized, and PPT nanoparticles were fabricated by the reprecipitation method. It was found that these nanoparticles show much higher cytotoxity for cancer cells as compared to etoposide, which is an analog of PPT.

Original language	English
Pages (from-to)	900-901
Number of pages	2
Journal	Chemistry Letters
Volume	42
Issue number	8
DOIs	https://doi.org/10.1246/cl.130224
Publication status	Published - 2013

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abstract = "Drug nanoparticles of water-insoluble bioactive compounds are potentially applicable in next-generation drug delivery systems (DDSs). As an example of such nanoparticles, the dimeric podophyllotoxin (PPT) was synthesized, and PPT nanoparticles were fabricated by the reprecipitation method. It was found that these nanoparticles show much higher cytotoxity for cancer cells as compared to etoposide, which is an analog of PPT.",

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AU - Ikuta, Yoshikazu

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AU - Oikawa, Hidetoshi

AU - Kasai, Hitoshi

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AB - Drug nanoparticles of water-insoluble bioactive compounds are potentially applicable in next-generation drug delivery systems (DDSs). As an example of such nanoparticles, the dimeric podophyllotoxin (PPT) was synthesized, and PPT nanoparticles were fabricated by the reprecipitation method. It was found that these nanoparticles show much higher cytotoxity for cancer cells as compared to etoposide, which is an analog of PPT.

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Fabrication of pure nanodrugs of podophyllotoxin dimer and their anticancer activity

Abstract

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