Fabrication of tissue compatible phospholipid polymer matrix for 3D cell culture

Eri Maeta; Tomohiro Konno; Madoka Takai; Kazuhiko Ishihara

Fabrication of tissue compatible phospholipid polymer matrix for 3D cell culture

Eri Maeta, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to conference › Paper › peer-review

Abstract

Recently, tissue engineering scaffolds are investigated from various biological materials. In this study, we use a phospholipid polymer (PMBN) composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and p-nitrophenyloxycarbonyl poly(oxyethylene)methacrylate (MEO ₂NP). PMBN hydrogel was fabricated by reaction with Bis (3-aminopropyl) poly (ethylene oxide) , in order to achieve a novel polymer matrix for cell culture that enables to control cell adhesions. The PMBN hydrogel has uniform several micrometers porous texture, therefore , PMBN hydrogel conjugated the adhesion molecule, Arg-Gly-Asp-Ser(RGDS), would become novel scaffold for 3D cell culture.

Original language	English
Pages	5233-5234
Number of pages	2
Publication status	Published - 2005 Dec 1
Externally published	Yes
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sept 20 → 2005 Sept 22

Other

Other	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

Keywords

3D Scaffold
Bio-conjugate
Hydrogel
Phospholipid polymer

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Fabrication of tissue compatible phospholipid polymer matrix for 3D cell culture",

abstract = "Recently, tissue engineering scaffolds are investigated from various biological materials. In this study, we use a phospholipid polymer (PMBN) composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and p-nitrophenyloxycarbonyl poly(oxyethylene)methacrylate (MEO 2NP). PMBN hydrogel was fabricated by reaction with Bis (3-aminopropyl) poly (ethylene oxide) , in order to achieve a novel polymer matrix for cell culture that enables to control cell adhesions. The PMBN hydrogel has uniform several micrometers porous texture, therefore , PMBN hydrogel conjugated the adhesion molecule, Arg-Gly-Asp-Ser(RGDS), would become novel scaffold for 3D cell culture.",

keywords = "3D Scaffold, Bio-conjugate, Hydrogel, Phospholipid polymer",

author = "Eri Maeta and Tomohiro Konno and Madoka Takai and Kazuhiko Ishihara",

year = "2005",

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TY - CONF

T1 - Fabrication of tissue compatible phospholipid polymer matrix for 3D cell culture

AU - Maeta, Eri

AU - Konno, Tomohiro

AU - Takai, Madoka

AU - Ishihara, Kazuhiko

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Recently, tissue engineering scaffolds are investigated from various biological materials. In this study, we use a phospholipid polymer (PMBN) composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and p-nitrophenyloxycarbonyl poly(oxyethylene)methacrylate (MEO 2NP). PMBN hydrogel was fabricated by reaction with Bis (3-aminopropyl) poly (ethylene oxide) , in order to achieve a novel polymer matrix for cell culture that enables to control cell adhesions. The PMBN hydrogel has uniform several micrometers porous texture, therefore , PMBN hydrogel conjugated the adhesion molecule, Arg-Gly-Asp-Ser(RGDS), would become novel scaffold for 3D cell culture.

AB - Recently, tissue engineering scaffolds are investigated from various biological materials. In this study, we use a phospholipid polymer (PMBN) composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), and p-nitrophenyloxycarbonyl poly(oxyethylene)methacrylate (MEO 2NP). PMBN hydrogel was fabricated by reaction with Bis (3-aminopropyl) poly (ethylene oxide) , in order to achieve a novel polymer matrix for cell culture that enables to control cell adhesions. The PMBN hydrogel has uniform several micrometers porous texture, therefore , PMBN hydrogel conjugated the adhesion molecule, Arg-Gly-Asp-Ser(RGDS), would become novel scaffold for 3D cell culture.

KW - 3D Scaffold

KW - Bio-conjugate

KW - Hydrogel

KW - Phospholipid polymer

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M3 - Paper

AN - SCOPUS:33645648125

SP - 5233

EP - 5234

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Fabrication of tissue compatible phospholipid polymer matrix for 3D cell culture

Abstract

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Keywords

ASJC Scopus subject areas

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