Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)

Shigesaburo Miyakoshi; Masahiro Kami; Yukiko Kishi; Naoko Murashige; Koichiro Yuji; Eiji Kusumi; Tomoko Matsumura; Yasushi Onishi; Kazuhiko Kobayashi; Sung Won Kim; Tamae Hamaki; Yoichi Takaue; Shuichi Taniguchi

doi:10.1080/10428190400004497

Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)

Shigesaburo Miyakoshi, Masahiro Kami, Yukiko Kishi, Naoko Murashige, Koichiro Yuji, Eiji Kusumi, Tomoko Matsumura, Yasushi Onishi, Kazuhiko Kobayashi, Sung Won Kim, Tamae Hamaki, Yoichi Takaue, Shuichi Taniguchi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 54-year-old man with chronic idiopathic myelofibrosis (CIMF) underwent RIST. His clinical course had been uneventful until day 60, when splenomegaly reappeared. Hepatic dysfunction developed on day 75. Recipient-type hematopoiesis increased to 51% on day 90. After rapid tapering of cyclosporin, serum levels of AST and ALP normalized in parallel with recovery of complete chimerism on day 134. Yet, jaundice progressed. He died of liver failure on day 176. Postmortem examination revealed neither GVHD nor VOD. Graft rejection following RIST for CIMF may lead to fatal hepatic damage through extramedullary hematopoiesis in the liver or cytokine-mediated immune dysregulations.

Original language	English
Pages (from-to)	2513-2516
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	45
Issue number	12
DOIs	https://doi.org/10.1080/10428190400004497
Publication status	Published - 2004 Dec
Externally published	Yes

Keywords

Allogeneic hematopoietic stem-cell transplantation
Extramedullary hematopoiesis
Graft failure
Graft-vs.-host disease
Hepatic venoocclusive disease

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Miyakoshi, S., Kami, M., Kishi, Y., Murashige, N., Yuji, K., Kusumi, E., Matsumura, T., Onishi, Y., Kobayashi, K., Kim, S. W., Hamaki, T., Takaue, Y., & Taniguchi, S. (2004). Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF). Leukemia and Lymphoma, 45(12), 2513-2516. https://doi.org/10.1080/10428190400004497

Miyakoshi, S, Kami, M, Kishi, Y, Murashige, N, Yuji, K, Kusumi, E, Matsumura, T, Onishi, Y, Kobayashi, K, Kim, SW, Hamaki, T, Takaue, Y & Taniguchi, S 2004, 'Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)', Leukemia and Lymphoma, vol. 45, no. 12, pp. 2513-2516. https://doi.org/10.1080/10428190400004497

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title = "Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)",

abstract = "A 54-year-old man with chronic idiopathic myelofibrosis (CIMF) underwent RIST. His clinical course had been uneventful until day 60, when splenomegaly reappeared. Hepatic dysfunction developed on day 75. Recipient-type hematopoiesis increased to 51% on day 90. After rapid tapering of cyclosporin, serum levels of AST and ALP normalized in parallel with recovery of complete chimerism on day 134. Yet, jaundice progressed. He died of liver failure on day 176. Postmortem examination revealed neither GVHD nor VOD. Graft rejection following RIST for CIMF may lead to fatal hepatic damage through extramedullary hematopoiesis in the liver or cytokine-mediated immune dysregulations.",

keywords = "Allogeneic hematopoietic stem-cell transplantation, Extramedullary hematopoiesis, Graft failure, Graft-vs.-host disease, Hepatic venoocclusive disease",

author = "Shigesaburo Miyakoshi and Masahiro Kami and Yukiko Kishi and Naoko Murashige and Koichiro Yuji and Eiji Kusumi and Tomoko Matsumura and Yasushi Onishi and Kazuhiko Kobayashi and Kim, {Sung Won} and Tamae Hamaki and Yoichi Takaue and Shuichi Taniguchi",

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doi = "10.1080/10428190400004497",

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AU - Miyakoshi, Shigesaburo

AU - Kami, Masahiro

AU - Kishi, Yukiko

AU - Murashige, Naoko

AU - Yuji, Koichiro

AU - Kusumi, Eiji

AU - Matsumura, Tomoko

AU - Onishi, Yasushi

AU - Kobayashi, Kazuhiko

AU - Kim, Sung Won

AU - Hamaki, Tamae

AU - Takaue, Yoichi

AU - Taniguchi, Shuichi

PY - 2004/12

Y1 - 2004/12

N2 - A 54-year-old man with chronic idiopathic myelofibrosis (CIMF) underwent RIST. His clinical course had been uneventful until day 60, when splenomegaly reappeared. Hepatic dysfunction developed on day 75. Recipient-type hematopoiesis increased to 51% on day 90. After rapid tapering of cyclosporin, serum levels of AST and ALP normalized in parallel with recovery of complete chimerism on day 134. Yet, jaundice progressed. He died of liver failure on day 176. Postmortem examination revealed neither GVHD nor VOD. Graft rejection following RIST for CIMF may lead to fatal hepatic damage through extramedullary hematopoiesis in the liver or cytokine-mediated immune dysregulations.

AB - A 54-year-old man with chronic idiopathic myelofibrosis (CIMF) underwent RIST. His clinical course had been uneventful until day 60, when splenomegaly reappeared. Hepatic dysfunction developed on day 75. Recipient-type hematopoiesis increased to 51% on day 90. After rapid tapering of cyclosporin, serum levels of AST and ALP normalized in parallel with recovery of complete chimerism on day 134. Yet, jaundice progressed. He died of liver failure on day 176. Postmortem examination revealed neither GVHD nor VOD. Graft rejection following RIST for CIMF may lead to fatal hepatic damage through extramedullary hematopoiesis in the liver or cytokine-mediated immune dysregulations.

KW - Allogeneic hematopoietic stem-cell transplantation

KW - Extramedullary hematopoiesis

KW - Graft failure

KW - Graft-vs.-host disease

KW - Hepatic venoocclusive disease

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Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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