Feasibility studies towards future self-sufficient supply of the 99Mo-99mTc isotopes with Japanese accelerators

Kozi Nakai, Naruto Takahashi, Jun Hatazawa, Atsushi Shinohara, Yoshihiko Hayashi, Hayato Ikeda, Yasukazu Kanai, Tadashi Watabe, Mitsuhiro Fukuda, Kichiji Hatanaka

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


In order to establish a self-sufficient supply of 99mTc, we studied feasibilities to produce its parent nucleus, 99Mo, using Japanese accelerators. The daughter nucleus, 99mTc, is indispensable for medical diagnosis. 99Mo has so far been imported from abroad, which is separated from fission products generated in nuclear reactors using enriched 235U fuel. We investigated 99mTc production possibilities based on the following three scenarios: (1) 99Mo production by the (n, 2n) reaction by spallation neutrons at the J-PARC injector, LINAC; (2) 99Mo production by the (p, pn) reaction at Ep = 50-80 MeV proton at the RCNP cyclotron; (3) 99mTc direct production with a 20MeV proton beam from the PET cyclotron. Among these three scenarios, scenario (1) is for a scheme on a global scale, scenario (2) works in a local area, and both cases take a long time for negotiations. Scenario (3) is attractive because we can use nearly 50 PET cyclotrons in Japan for 99mTc production. We here consider both the advantages and disadvantages among the three scenarios by taking account of the Japanese accelerator situation.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Issue number10
Publication statusPublished - 2014
Externally publishedYes


  • Accelerator production
  • J-PARC
  • Mo-Tc
  • PET-cyclotron
  • Tc generator

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Feasibility studies towards future self-sufficient supply of the 99Mo-99mTc isotopes with Japanese accelerators'. Together they form a unique fingerprint.

Cite this