TY - JOUR
T1 - Feasibility study of fluorine-18 labeled dopa for melanoma imaging
AU - Ishiwata, Kiichi
AU - Ido, Tatsuo
AU - Takahashi, Toshihiro
AU - Iwata, Ren
AU - Brady, Frank
AU - Hatazawa, Jun
AU - Itoh, Masatoshi
N1 - Funding Information:
Acknowledgements-This work was supportedb y a Grant-in-Aid for CancerR esearchN o. 6301003f3ro m theM inistry of Education, Sciencea nd Culture, Japan. The authors appreciatet he Cancer Cell Repository-i n the Research Institutef or Tuberculosisa nd Cancer.T ohoku Universitv. for supplyingf our non-melanomat umor cells and Dr I: Suda, Meet Co., Tokyo, for supplying melanomaB 16-bearing mice. The authors are also grateful for the cooperationo f the staff at the Cyclotrona nd Radioisotope Center.
PY - 1989
Y1 - 1989
N2 - Feasibility of fluorine-18 labeled l-dopa for melanoma imaging was investigated. In B16 melanoma-bearing mice given 2-[18F]fluoro-l-dopa, the radioactivity in the B16 decreased for the first 60 min and then remained constant, while all other tissues investigated decreased with time. High tumor uptake ratios for all other tissues except for the pancreas were obtained at 120 min. 6-[18F]Fluoro-l-dopa showed a similar tissue distribution. However, the B16 uptake was about half that value for the 2-fluoro analogue. A higher incorporation rate of 2-[18F]fluoro-l-dopa into the acid-precipitable fraction of the melanoma also showed that the 2-[18F]fluoro-l-dopa was a preferable melanin precursor. Among the four kinds of non-melanoma tumors in mice or rats three tumors showed an uptake of 2-[18F]fluoro-l-dopa similar to the B16 at 60 min. However, larger melanoma-to-tissue uptake ratios were observed when compared to non-melanoma tumors.
AB - Feasibility of fluorine-18 labeled l-dopa for melanoma imaging was investigated. In B16 melanoma-bearing mice given 2-[18F]fluoro-l-dopa, the radioactivity in the B16 decreased for the first 60 min and then remained constant, while all other tissues investigated decreased with time. High tumor uptake ratios for all other tissues except for the pancreas were obtained at 120 min. 6-[18F]Fluoro-l-dopa showed a similar tissue distribution. However, the B16 uptake was about half that value for the 2-fluoro analogue. A higher incorporation rate of 2-[18F]fluoro-l-dopa into the acid-precipitable fraction of the melanoma also showed that the 2-[18F]fluoro-l-dopa was a preferable melanin precursor. Among the four kinds of non-melanoma tumors in mice or rats three tumors showed an uptake of 2-[18F]fluoro-l-dopa similar to the B16 at 60 min. However, larger melanoma-to-tissue uptake ratios were observed when compared to non-melanoma tumors.
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U2 - 10.1016/0883-2897(89)90102-5
DO - 10.1016/0883-2897(89)90102-5
M3 - Article
C2 - 2777577
AN - SCOPUS:45249130083
SN - 0969-8051
VL - 16
SP - 371
EP - 374
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 4
ER -