First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

Keizo Ishii; Y. Kikuchi; S. Matsuyama; Y. Kanai; Koji Kotani; T. Ito; H. Yamazaki; Y. Funaki; Ren Iwata; M. Itoh; Kazuhiko Yanai; J. Hatazawa; N. Itoh; N. Tanizaki; D. Amano; M. Yamada; T. Yamaguchi

doi:10.1016/j.nima.2007.03.018

First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

Keizo Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, Koji Kotani, T. Ito, H. Yamazaki, Y. Funaki, Ren Iwata, M. Itoh, Kazuhiko Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

An animal PET scanner using CdTe detectors was developed for the purpose of biomedical study using mice and rats. A spatial resolution of 0.8 mm FWHM within the central 20 mm-diameter of the field of view (FOV) was obtained by small CdTe elements of 1.1 mm×5.0 mm×1.0 mm. This spatial resolution is the first achievement of a practical semiconductor animal PET scanner. The determination of the depth of the γ interaction in the detector was carried out by the use of two detector layers. The FOV is 64 mm in diameter and 26 mm in axis. Fine [¹⁸F]FDG images of the heads of a mouse and a rat, where the cerebral cortex, the gray matter and the corpus striatum could be respectively distinguished, were successfully obtained. This work inspires the dawn of the high resolution semiconductor PET scanner age as the next generation.

Original language	English
Pages (from-to)	435-440
Number of pages	6
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	576
Issue number	2-3
DOIs	https://doi.org/10.1016/j.nima.2007.03.018
Publication status	Published - 2007 Jun 21

Keywords

Animal PET
CdTe
High resolution
Positron emission tomograph
Semiconductor detector

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nima.2007.03.018

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Ishii, K., Kikuchi, Y., Matsuyama, S., Kanai, Y., Kotani, K., Ito, T., Yamazaki, H., Funaki, Y., Iwata, R., Itoh, M., Yanai, K., Hatazawa, J., Itoh, N., Tanizaki, N., Amano, D., Yamada, M., & Yamaguchi, T. (2007). First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 576(2-3), 435-440. https://doi.org/10.1016/j.nima.2007.03.018

First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner. / Ishii, Keizo; Kikuchi, Y.; Matsuyama, S. et al.
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 576, No. 2-3, 21.06.2007, p. 435-440.

Research output: Contribution to journal › Article › peer-review

Ishii, K, Kikuchi, Y , Matsuyama, S, Kanai, Y, Kotani, K, Ito, T, Yamazaki, H, Funaki, Y, Iwata, R, Itoh, M, Yanai, K, Hatazawa, J, Itoh, N, Tanizaki, N, Amano, D, Yamada, M & Yamaguchi, T 2007, 'First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 576, no. 2-3, pp. 435-440. https://doi.org/10.1016/j.nima.2007.03.018

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abstract = "An animal PET scanner using CdTe detectors was developed for the purpose of biomedical study using mice and rats. A spatial resolution of 0.8 mm FWHM within the central 20 mm-diameter of the field of view (FOV) was obtained by small CdTe elements of 1.1 mm×5.0 mm×1.0 mm. This spatial resolution is the first achievement of a practical semiconductor animal PET scanner. The determination of the depth of the γ interaction in the detector was carried out by the use of two detector layers. The FOV is 64 mm in diameter and 26 mm in axis. Fine [18F]FDG images of the heads of a mouse and a rat, where the cerebral cortex, the gray matter and the corpus striatum could be respectively distinguished, were successfully obtained. This work inspires the dawn of the high resolution semiconductor PET scanner age as the next generation.",

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note = "Funding Information: We are indebted to Dr. V.A. Yardley for helpful discussion and critical reading of the manuscript. This work was supported by a Grant-in-Aid for Specially Promoted Research no. 17002010 (K. Ishii) of the ministry of Education, Culture, Sports, Science and Technology.",

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AU - Kotani, Koji

AU - Ito, T.

AU - Yamazaki, H.

AU - Funaki, Y.

AU - Iwata, Ren

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AU - Tanizaki, N.

AU - Amano, D.

AU - Yamada, M.

AU - Yamaguchi, T.

N1 - Funding Information: We are indebted to Dr. V.A. Yardley for helpful discussion and critical reading of the manuscript. This work was supported by a Grant-in-Aid for Specially Promoted Research no. 17002010 (K. Ishii) of the ministry of Education, Culture, Sports, Science and Technology.

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N2 - An animal PET scanner using CdTe detectors was developed for the purpose of biomedical study using mice and rats. A spatial resolution of 0.8 mm FWHM within the central 20 mm-diameter of the field of view (FOV) was obtained by small CdTe elements of 1.1 mm×5.0 mm×1.0 mm. This spatial resolution is the first achievement of a practical semiconductor animal PET scanner. The determination of the depth of the γ interaction in the detector was carried out by the use of two detector layers. The FOV is 64 mm in diameter and 26 mm in axis. Fine [18F]FDG images of the heads of a mouse and a rat, where the cerebral cortex, the gray matter and the corpus striatum could be respectively distinguished, were successfully obtained. This work inspires the dawn of the high resolution semiconductor PET scanner age as the next generation.

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First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner

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