First clinical application of octacalcium phosphate collagen composite in human bone defect

Tadashi Kawai, Seishi Echigo, Keiko Matsui, Yuji Tanuma, Tetsu Takahashi, Osamu Suzuki, Shinji Kamakura

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


We have previously demonstrated that octacalcium phosphate (OCP) collagen composite (OCP/collagen) promotes bone regeneration in a critical-sized bone defect of a rodent or canine model. This study was designed to investigate the bone regeneration of OCP/collagen in human bone defect as a first clinical trial. Two patients who had a radicular cyst or apical periodontitis consented to participate in our clinical study, and OCP/collagen was implanted into the defects after operation. Radiographic examination showed effective bone healing in each bone defect at 3 or 6 months. Likewise, computed tomography value significantly increased after implantation. Postoperative wound healing was uneventful, and neither infection nor allergic reaction against OCP/collagen was observed for the entire period. This study demonstrated that OCP/collagen would be safely used and enhanced bone regeneration in human bone defects. To reinforce the efficacy of OCP/collagen as a bone substitute material, it should be compared with other suitable comparators in the future.

Original languageEnglish
Pages (from-to)1336-1341
Number of pages6
JournalTissue Engineering - Part A.
Issue number7-8
Publication statusPublished - 2014 Apr 1


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