TY - JOUR
T1 - Fish oil and omega-3 fatty acids in cardiovascular disease
T2 - Do they really work?
AU - Kromhout, Daan
AU - Yasuda, Satoshi
AU - Geleijnse, Johanna M.
AU - Shimokawa, Hiroaki
N1 - Funding Information:
The work by the authors in this review article was supported in part by the Netherlands Heart Foundation, the Netherlands Prevention Foundation, the National Institutes of Health, USA, and an unrestricted grant of Unilever R&D (to D.K.), and the grants from the Japanese Ministry of Education, Sports, and Culture, Tokyo, Japan, and those from the Japanese Ministry of Health, Labour and Welfare, Tokyo, Japan (to H.S.).
PY - 2012/2
Y1 - 2012/2
N2 - Omega-3 fatty acids, which are found abundantly in fish oil, exert pleiotropic cardiometabolic effects with a diverse range of actions. The results of previous studies raised a lot of interest in the role of fish oil and omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases. The present review will focus on the current clinical uses of omega-3 fatty acids and provide an update on their effects. Since recently published trials in patients with coronary artery diseases or post-myocardial infarction did not show an effect of omega-3 fatty acids on major cardiovascular endpoints, this review will examine the limitations of those data and suggest recommendations for the use of omega-3 fatty acids.
AB - Omega-3 fatty acids, which are found abundantly in fish oil, exert pleiotropic cardiometabolic effects with a diverse range of actions. The results of previous studies raised a lot of interest in the role of fish oil and omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases. The present review will focus on the current clinical uses of omega-3 fatty acids and provide an update on their effects. Since recently published trials in patients with coronary artery diseases or post-myocardial infarction did not show an effect of omega-3 fatty acids on major cardiovascular endpoints, this review will examine the limitations of those data and suggest recommendations for the use of omega-3 fatty acids.
KW - Cardiovascular disease
KW - Fish oils
UR - http://www.scopus.com/inward/record.url?scp=84857175897&partnerID=8YFLogxK
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U2 - 10.1093/eurheartj/ehr362
DO - 10.1093/eurheartj/ehr362
M3 - Review article
C2 - 21933782
AN - SCOPUS:84857175897
SN - 0195-668X
VL - 33
SP - 436
EP - 443
JO - European Heart Journal
JF - European Heart Journal
IS - 4
ER -
