FLI1 Oncogene

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Friend leukemia integration-1 (Fli1) is a member of the Ets (E26 transformation-specific) transcription factor family, which was initially identified as a proto-oncogene in Friend virus-induced erythroleukemia in mice. In humans, Fli1 gene is rearranged in 90% of Ewing sarcoma family of tumors, which includes morphological variants of Ewing sarcoma and peripheral primitive neuroectodermal tumor. Under physiological conditions, Fli1 is expressed at high levels in both hematopoietic and endothelial cells. Fli1 is also expressed in dermal fibroblasts even though the levels are relatively lower compared with those cells. Consistently, Fli1 plays a pivotal role in megakaryocytic differentiation and myelomonocytic, erythroid, and natural killer (NK) cell development, in vascular development and angiogenesis, and in the process of extracellular matrix remodeling. Altered expression of Fli1 in these cell types may be associated with the developmental process of systemic lupus erythematosus and systemic sclerosis.

Original languageEnglish
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages64-66
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
Publication statusPublished - 2013 Feb 27

Keywords

  • B cells
  • Endothelial cells
  • Erythroid cells
  • Ewing sarcoma family of tumor
  • Fibroblasts
  • Fli1
  • Granulocytic cells
  • Jacobsen or Paris-Trousseau syndrome
  • Lupus nephritis
  • Megakaryocyte
  • NK cells
  • Systemic sclerosis
  • T cells
  • TGF-β

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