TY - JOUR
T1 - Fluctuations in antibody titers against enterovirus D68 in pediatric sera collected in a community before, during, and after a possible outbreak
AU - Kadji, Francois Marie Ngako
AU - Nishimura, Hidekazu
AU - Okamoto, Michiko
AU - Sato, Ko
AU - Ohmiya, Suguru
AU - Ito, Hiroko
AU - Suzuki, Akira
AU - Nagai, Yukio
AU - Oshitani, Hitoshi
N1 - Funding Information:
Acknowledgments This work was financially supported by the Clinical Research Division of Sendai Medical Center; the Research Program on Promoting Development of Innovative Drugs against Emerging and Reemerging Infectious Diseases at Japan Agency for Medical Research and Development (AMED); the Japanese Initiative for Global of Research Network on Infections Diseases (J-GRID) at AMED; the Japan Society for Promotion of Scieuce (JSPS) KAKENHI; Miuistry of Health, Labour and Welfare.
Funding Information:
This work was financially supported by the Clinical Research Division of Sendai Medical Center; the Research Program on Promoting Development of Innovative Drugs against Emerging and Reemerging Infectious Diseases at Japan Agency for Medical Research and Development (AMED); the Japanese Initiative for Global of Research Network on Infections Diseases (J-GRID) at AMED; the Japan Society for Promotion of Science (JSPS) KAKENHI; Miuistry of Health, Labour and Welfare.
Publisher Copyright:
© 2020, National Institute of Health. All rights reserved.
PY - 2020
Y1 - 2020
N2 - We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0–6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children’s immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.
AB - We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0–6 years; without symptoms of infectious diseases) in the Sendai community collected during 4 periods (1 year before, 6 months before, immediately after, and 1 year after the possible outbreak period) were analyzed using the neutralization antibody titer assay to determine community children’s immunity levels against EV-D68 infection. The immunity levels were confirmed to have increased during the possible outbreak period and to have gradually waned over 1 year without another outbreak. These results provide background information supporting the results of our previous hospital-based surveillance study.
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U2 - 10.7883/yoken.JJID.2019.056
DO - 10.7883/yoken.JJID.2019.056
M3 - Short survey
C2 - 31474700
AN - SCOPUS:85078550772
SN - 1344-6304
VL - 73
SP - 55
EP - 57
JO - Japanese medical journal
JF - Japanese medical journal
IS - 1
ER -
